Mapt^{tm3(Hdac2)Jae}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm3(Hdac2)Jae}
• Name: microtubule-associated protein tau; targeted mutation 3, Rudolf Jaenisch
• MGI ID: MGI:3844982
• Synonyms: HDAC2OE, Tau^HDAC2
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm3(Hdac2)Jae} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148391
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Coding sequence for the mouse Hdac2 protein was placed in-frame with exon 1 of the gene locus creating a fusion protein containing the first 31 amino-acids of the endogenous locus. A 2-3 fol expression of Hdac2 was confirmed in the CA1 region of the hippocampus by immunohistofluorescence. Hdac2 activity was confirmed by decreased levels of acetylation present in the same region as expression. (J:148391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 428 strains or lines available

References

• Original: J:148391 Guan JS, et al., HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 2009 May 7;459(7243):55-60
• All: 1 reference(s)