About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxp3
forkhead box P3
MGI:1891436
162 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
\Altretm1.1Hbgl/\Altretm1.1Hbgl
\Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal liver morphology J:342907
abnormal mitochondrial morphology J:342907
abnormal mitochondrial physiology J:342907
abnormal regulatory T cell physiology J:342907
decreased mitochondrial size J:342907
decreased regulatory T cell number J:342907
decreased T cell number J:342907
increased CD8-positive, alpha-beta T cell number J:342907
increased circulating alanine transaminase level J:342907
increased interleukin-17 secretion J:342907
increased liver tumor incidence J:342907
increased memory T cell number J:342907
increased regulatory T cell apoptosis J:342907
increased susceptibility to diet-induced hepatic steatosis J:342907
liver fibrosis J:342907
premature death J:342907
\Aregtm2c(EUCOMM)Hmgu/\Aregtm2c(EUCOMM)Hmgu
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		decreased blood oxygen saturation level J:224904
decreased body surface temperature J:224904
normal immune system phenotype J:224904
increased susceptibility to Orthomyxoviridae infection J:224904
normal mortality/aging J:224904
\B2mtm1Jae/\B2mtm1Jae
\Foxp3sf\Otcspf/Y
involves: 129/Rl * 129S2/SvPas 		abnormal immune system organ morphology J:20865
abnormal interleukin level J:20865
abnormal lymph node morphology J:20865
abnormal tumor necrosis factor level J:20865
anemia J:20865
decreased body size J:20865
decreased hematocrit J:20865
dermatitis J:20865
enlarged lymph nodes J:20865
enlarged spleen J:20865
increased CD4-positive, alpha-beta T cell number J:20865
increased IgG level J:20865
increased IgM level J:20865
increased immunoglobulin level J:20865
increased plasma cell number J:20865
\B9d2/Tgfb1tm1Flv/\B9d2+
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		normal growth/size/body region phenotype J:169839
normal immune system phenotype J:169839
increased regulatory T cell number J:169839
\B9d2/Tgfb1tm1Flv/\Tgfb1tm2Flv
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		normal growth/size/body region phenotype J:169839
normal immune system phenotype J:169839
increased regulatory T cell number J:169839
\Bcl2l11tm6.1Boui/\Bcl2l11tm6.1Boui
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased regulatory T cell number J:208318
\Becn1tm1Smoc/\Becn1tm1Smoc
\Foxp3tm4(YFP/icre)Ayr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:306129
\Becn1tm1Smoc/\Becn1tm1Smoc
\Zfp91tm1Smoc/\Zfp91tm1Smoc
\Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:306129
\Cd4tm1Litt/\Cd4tm1Litt
\Foxp3sf\Otcspf/Y
involves: 129/Rl * 129S2/SvPas 		abnormal CD8-positive, alpha beta T cell morphology J:20865
abnormal cytokine secretion J:20865
abnormal immune system organ morphology J:20865
enlarged lymph nodes J:20865
increased IgG level J:20865
increased IgM level J:20865
increased interleukin-4 secretion J:20865
increased interleukin-6 secretion J:20865
increased tumor necrosis factor secretion J:20865
premature death J:20865
\Cd28tm1Ltu/\Cd28tm1Ltu
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal eyelid morphology J:194503
decreased locomotor activity J:194503
decreased regulatory T cell number J:194503
decreased T cell proliferation J:194503
enlarged lymph nodes J:194503
enlarged spleen J:194503
focal hair loss J:194503
hunched posture J:194503
increased activated T cell number J:194503
increased B cell number J:194503
increased susceptibility to autoimmune disorder J:194503
increased susceptibility to experimental autoimmune encephalomyelitis J:194503
ruffled hair J:194503
skin inflammation J:194503
skin lesions J:194503
\Cishtm1.1Cdon/\Cishtm1.1Cdon
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:204829
\Ctla4tm1Saka/\Ctla4tm1Saka
\Foxp3tm1(cre)Saka/Y
involves: BALB/c 		abnormal immunoglobulin level J:140085
abnormal liver morphology J:140085
abnormal regulatory T cell physiology J:140085
abnormal splenic cell ratio J:140085
enlarged heart J:140085
increased autoantibody level J:140085
increased IgE level J:140085
increased IgG level J:140085
increased inflammatory response J:140085
increased interferon-gamma secretion J:140085
increased interleukin-2 secretion J:140085
increased interleukin-4 secretion J:140085
increased regulatory T cell number J:140085
lung inflammation J:140085
lymph node hyperplasia J:140085
myocarditis J:140085
premature death J:140085
salivary gland inflammation J:140085
spleen hyperplasia J:140085
stomach inflammation J:140085
\Ctps1tm1c(KOMP)Wtsi/\Ctps1tm1c(KOMP)Wtsi
\Tg(Cd4-cre)1Cwi/0
\Foxp3sf/Y
\Rag1tm1Mom/\Rag1+
mixed 		decreased body weight J:348981
decreased inflammatory response J:348981
decreased regulatory T cell number J:348981
decreased T cell proliferation J:348981
enlarged spleen J:348981
thymus hypoplasia J:348981
\Dicer1tm1Bdh/\Dicer1tm1Bdh
\Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ 		blood vessel inflammation J:138683
enlarged lymph nodes J:138683
enlarged spleen J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
\Dicer1tm1Bdh/\Dicer1tm1Bdh
\Foxp3tm4(YFP/icre)Ayr/\Foxp3tm4(YFP/icre)Ayr
involves: 129S1/Sv * 129X1/SvJ 		blood vessel inflammation J:138683
enlarged lymph nodes J:138683
enlarged spleen J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
\Droshatm1Litt/\Droshatm1.1Litt
\Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal interferon-gamma secretion J:138683
abnormal interleukin-4 secretion J:138683
abnormal T cell activation J:138683
blood vessel inflammation J:138683
enlarged lymph nodes J:138683
enlarged spleen J:138683
increased CD8-positive, alpha-beta T cell number J:138683
increased leukocyte cell number J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
\Droshatm1Litt/\Droshatm1.1Litt
\Foxp3tm4(YFP/icre)Ayr/\Foxp3tm4(YFP/icre)Ayr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal interferon-gamma secretion J:138683
abnormal interleukin-4 secretion J:138683
abnormal regulatory T cell morphology J:138683
abnormal T cell activation J:138683
blood vessel inflammation J:138683
enlarged lymph nodes J:138683
enlarged spleen J:138683
increased CD8-positive, alpha-beta T cell number J:138683
increased leukocyte cell number J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
\Foxo1tm1Flv/\Foxo1tm1Flv
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		abnormal inflammatory response J:189962
abnormal regulatory T cell physiology J:189962
abnormal skin appearance J:189962
abnormal tail morphology J:189962
enlarged lymph nodes J:189962
enlarged spleen J:189962
hunched posture J:189962
increased CD4-positive, alpha-beta T cell number J:189962
increased CD8-positive, alpha-beta T cell number J:189962
increased interferon-gamma secretion J:189962
increased regulatory T cell number J:189962
increased T cell number J:189962
increased T cell proliferation J:189962
paralysis J:189962
premature death J:189962
\Foxo1tm1Flv/\Foxo1tm1Flv
\Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/\Gt(ROSA)26Sor+
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:189962
normal mortality/aging J:189962
\Foxo1tm1Flv/\Foxo1tm1Flv
\Ifngtm1Ts/\Ifngtm1Ts
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ 		normal immune system phenotype J:189962
increased CD4-positive, alpha-beta T cell number J:189962
increased CD8-positive, alpha-beta T cell number J:189962
normal mortality/aging J:189962
\Foxp3sf\Otcspf/Y
involves: 129/Rl 		anemia J:20865
decreased body weight J:20865
decreased hematocrit J:20865
enlarged lymph nodes J:20865
enlarged spleen J:20865
increased CD4-positive, alpha-beta T cell number J:20865
postnatal lethality, incomplete penetrance J:20865
premature death J:20865
skin lesions J:20865
\Foxp3tm1.1Ayr/\Foxp3tm1.1Ayr
\Mir146tm1.1Bal/\Mir146tm1.1Bal
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal lymphocyte physiology J:167922
blepharitis J:167922
conjunctivitis J:167922
decreased interferon-gamma secretion J:167922
dermatitis J:167922
increased regulatory T cell number J:167922
premature aging J:167922
\Foxp3tm1.1Ayr/Y
\Rag1tm1Mom/\Rag1tm1Mom
\Tg(TcraTcrb)425Cbn/0
Not Specified 		normal immune system phenotype J:97029
no abnormal phenotype detected J:97029
\Foxp3tm1.1Mal/\Foxp3tm1.1Mal
\Lattm1.1Mal/\Lattm1.1Mal
involves: 129S2/SvPas * C57BL/6 		abnormal regulatory T cell physiology J:131351
decreased regulatory T cell number J:131351
thymus hypoplasia J:131351
\Foxp3tm1Flv/\Foxp3+
\B9d2/Tgfb1tm1Flv/\Tgfb1tm2Flv
\Tg(Cd4-cre)1Cwi/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		increased regulatory T cell number J:123547
\Foxp3tm1Kuch/?
\Il6tm1Kopf/\Il6tm1Kopf
involves: 129S2/SvPas * C57BL/6 		abnormal CD4-positive T cell differentiation J:123352
decreased circulating interleukin-6 level J:123352
decreased interleukin-17 secretion J:123352
decreased susceptibility to experimental autoimmune encephalomyelitis J:123352
increased regulatory T cell number J:123352
\Foxp3tm1Tch/Y
\Stat6tm1Gru/\Stat6tm1Gru
C.129-Stat6tm1Gru Foxp3tm1Tch 		abnormal cytokine secretion J:117165
normal immune system phenotype J:117165
increased circulating interferon-gamma level J:117165
increased eosinophil cell number J:117165
lethality at weaning, complete penetrance J:117165
normal respiratory system phenotype J:117165
\Foxp3tm2.1(EGFP/cre)Shori/\Foxp3tm2.1(EGFP/cre)Shori
\Pdcd1tm1Hon/\Pdcd1tm1Hon
involves: 129 * 129S2/SvPas * C57BL/6 		premature death J:234397
\Foxp3tm2.1(EGFP/cre)Shori/Y
\Pdcd1tm1Hon/\Pdcd1tm1Hon
involves: 129 * 129S2/SvPas * C57BL/6 		decreased circulating lipase level J:234397
enlarged lymph nodes J:234397
enlarged spleen J:234397
increased effector memory T-helper cell number J:234397
increased susceptibility to autoimmune disorder J:234397
lymph node hyperplasia J:234397
pancreas atrophy J:234397
pancreas inflammation J:234397
premature death J:234397
spleen hyperplasia J:234397
\Foxp3tm2Ayr/\Foxp3+
\Rnf128tm1Cdon/\Rnf128tm1Cdon
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:160681
\Foxp3tm2Ayr/?
\Zap70rps/\Zap70rps
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:211510
abnormal double-positive T cell morphology J:211510
abnormal regulatory T cell number J:211510
abnormal T cell differentiation J:211510
decreased CD4-positive, alpha-beta T cell number J:211510
decreased CD8-positive, alpha-beta T cell number J:211510
normal immune system phenotype J:211510
\Foxp3tm3(HBEGF/GFP)Ayr/\Foxp3+
\Gpr174tm1Cys/\Gpr174+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		decreased susceptibility to experimental autoimmune encephalomyelitis J:222307
\Foxp3tm3(HBEGF/GFP)Ayr/\Foxp3tm3(HBEGF/GFP)Ayr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:117743
abnormal dendritic cell physiology J:117743
bradykinesia J:117743
cachexia J:117743
conjunctivitis J:117743
decreased T cell number J:117743
dermatitis J:117743
enlarged spleen J:117743
increased dendritic cell number J:117743
increased susceptibility to autoimmune disorder J:117743
increased susceptibility to induced morbidity/mortality J:117743
liver inflammation J:117743
lung inflammation J:117743
lymph node inflammation J:117743
weight loss J:117743
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
\Nr4a2tm1.1Pcn/\Nr4a2tm1.1Pcn
involves: 129S1/Sv * 129X1/SvJ 		abnormal regulatory T cell morphology J:205658
abnormal regulatory T cell physiology J:205658
\Foxp3tm4(YFP/icre)Ayr/\Foxp3tm4(YFP/icre)Ayr
\Ikzf4tm1Djr/\Ikzf4tm1Djr
involves: 129S1/Sv * 129X1/SvJ 		abnormal small intestine morphology J:294549
chronic inflammation J:294549
decreased regulatory T cell number J:294549
decreased small intestinal microvillus size J:294549
enlarged lymph nodes J:294549
enlarged spleen J:294549
glomerulonephritis J:294549
granulomatous inflammation J:294549
increased germinal center B cell number J:294549
increased immunoglobulin level J:294549
increased spleen B cell follicle number J:294549
increased spleen germinal center number J:294549
increased susceptibility to experimental autoimmune encephalomyelitis J:294549
increased T cell number J:294549
increased T follicular helper cell number J:294549
small intestinal inflammation J:294549
\Foxp3tm4(YFP/icre)Ayr/Y
\Zfp91tm1Smoc/\Zfp91tm1Smoc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:306129
decreased regulatory T cell number J:306129
increased CD8-positive, alpha-beta T cell number J:306129
increased incidence of tumors by chemical induction J:306129
increased susceptibility to autoimmune disorder J:306129
increased susceptibility to induced colitis J:306129
\Foxp3tm9(EGFP/cre/ERT2)Ayr/\Foxp3+
\Il1r2tm1.1Epi/\Il1r2tm1.1Epi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NTac 		abnormal adaptive immunity J:347877
abnormal alpha-beta T cell number J:347877
increased CD4-positive, alpha-beta T cell number J:347877
increased IgG level J:347877
increased spleen germinal center size J:347877
increased T follicular helper cell number J:347877
\Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/\Gt(ROSA)26Sor+
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:189962
\Il10tm1Roer/\Il10tm1Roer
\Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:134513
abnormal type IV hypersensitivity reaction J:134513
colitis J:134513
decreased interleukin-10 secretion J:134513
lung inflammation J:134513
\Itchtm1.1Alta/\Itchtm1.1Alta
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal immunoglobulin level J:204685
abnormal interleukin secretion J:204685
abnormal lymph organ size J:204685
abnormal lymphopoiesis J:204685
abnormal regulatory T cell physiology J:204685
abnormal T-helper 2 cell differentiation J:204685
abnormal T-helper 2 physiology J:204685
decreased CD4-positive, alpha-beta T cell number J:204685
dermatitis J:204685
enlarged lymph nodes J:204685
enlarged spleen J:204685
normal immune system phenotype J:204685
increased CD4-positive, alpha-beta T cell number J:204685
increased CD8-positive, alpha-beta T cell number J:204685
increased eosinophil cell number J:204685
increased IgA level J:204685
increased IgE level J:204685
increased IgG1 level J:204685
increased inflammatory response J:204685
increased interleukin-4 secretion J:204685
increased interleukin-5 secretion J:204685
increased interleukin-10 secretion J:204685
increased interleukin-13 secretion J:204685
increased interleukin-17 secretion J:204685
increased leukocyte cell number J:204685
increased regulatory T cell apoptosis J:204685
increased regulatory T cell number J:204685
lung inflammation J:204685
premature death J:204685
skin lesions J:204685
weight loss J:204685
\Itchtm1.1Alta/\Itchtm1.1Alta
\Gt(ROSA)26Sortm1Hjf/\Gt(ROSA)26Sor+
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:204685
increased inflammatory response J:204685
\Myd88tm1.1Medz/\Myd88tm1.1Medz
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:209373
\Nr4a1tm1Pcn/\Nr4a1tm1Pcn
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:205658
\Nr4a2tm1.1Pcn/\Nr4a2+
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal regulatory T cell morphology J:205658
\Pgdtm1.1Pse/\Pgdtm1.1Pse
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal CD4-positive helper T cell morphology J:313817
abnormal regulatory T cell physiology J:313817
blepharitis J:313817
decreased body size J:313817
ear inflammation J:313817
enlarged lymph nodes J:313817
enlarged spleen J:313817
increased circulating interferon-gamma level J:313817
increased circulating interleukin-4 level J:313817
increased circulating interleukin-5 level J:313817
increased circulating interleukin-17 level J:313817
increased IgA level J:313817
increased IgD level J:313817
increased IgE level J:313817
increased IgG2a level J:313817
increased IgG3 level J:313817
increased IgM level J:313817
increased interferon-gamma secretion J:313817
increased susceptibility to type I hypersensitivity reaction J:313817
increased T cell number J:313817
premature death J:313817
\Pgdtm1.1Pse/\Pgdtm1.1Pse
\Foxp3tm9(EGFP/cre/ERT2)Ayr/\Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		decreased tumor growth/size J:313817
\Socs1tm1Ayos/\Socs1tm1Ayos
\Foxp3tm4(YFP/icre)Ayr/\Foxp3+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		blepharitis J:167922
conjunctivitis J:167922
dermatitis J:167922
increased regulatory T cell number J:167922
\Tg(Foxp3-HBEGF/EGFP)23.2Spar/0
involves: C57BL/6NCrl 		abnormal pulmonary alveolus morphology J:125295
decreased regulatory T cell number J:125295
enlarged lymph nodes J:125295
enlarged spleen J:125295
epidermal hyperplasia J:125295
normal immune system phenotype J:125295
increased inflammatory response J:125295
increased spleen red pulp amount J:125295
increased spleen white pulp amount J:125295
increased susceptibility to type IV hypersensitivity reaction J:125295
insulitis J:125295
lung inflammation J:125295
lymph node hyperplasia J:125295
skin inflammation J:125295
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory