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Targeted Allele Detail
Symbol: Foxp3tm1Kuch
Name: forkhead box P3; targeted mutation 1, Vijay K Kuchroo
MGI ID: MGI:3718527
Synonyms: Fox3eGFP, Foxp3eGFP, Foxp3-eGFP, Foxp3-GFP, Foxp3/GFP+, Foxp3gfp.KI, Foxp3-GFP.KI, Foxp3-IRES-GFP
Gene: Foxp3  Location: ChrX:7445915-7461482 bp, + strand  Genetic Position: ChrX, 3.41 cM
Alliance: Foxp3tm1Kuch page
Germline Transmission:  Earliest citation of germline transmission: J:123469
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
Mutation detailsA bicistronic enhanced green fluorescent protein reporter (IRES-GFP) was inserted into the locus. EGFP can be used to faithfully track the expression of the endogenous gene. No disruption to Foxp3 gene function or expression is observed. (J:123469)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  56 strains or lines available
Original:  J:123469 Bettelli E, et al., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11;441(7090):235-8
All:  176 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory