Foxp3^tm1.1Mal
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm1.1Mal
• Name: forkhead box P3; targeted mutation 1.1, Bernard Malissen
• MGI ID: MGI:3773675
• Synonyms: FOXP3EGFP, Foxp3-GDL, Foxp3.LuciDTR-4, Foxp3^tm1Mal
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm1.1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131351
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The following sequences were inserted in the 3' UTR in exon 11: an IRES, the human diphtheria toxin receptor (HBEGF) cDNA coding region in-frame with the EGFP gene coding region, a loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site. Cre-mediated self-excision removed the cre+neo cassette in the male germline. The presence of the EGFP cassette does not interfeer with expression of the gene locus. EGFP expression occurs in Foxp3⁺ regulatory T cells. (J:131351)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 55 strains or lines available

References

• Original: J:131351 Wang Y, et al., Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J Immunol. 2008 Feb 1;180(3):1565-75
• All: 64 reference(s)