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Targeted Allele Detail
Symbol: Il6tm1Kopf
Name: interleukin 6; targeted mutation 1, Manfred Kopf
MGI ID: MGI:1857197
Synonyms: Il6-, IL-6-, IL-6 KO, Il6tm1Koe, Il6tm1Kopf
Gene: Il6  Location: Chr5:30218112-30224973 bp, + strand  Genetic Position: Chr5, 15.7 cM
Alliance: Il6tm1Kopf page
Germline Transmission:  Earliest citation of germline transmission: J:17360
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 2. RT-PCR experiments on RNA derived from LPS-stimulated macrophages of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA and bioassay experiments confirmed that no functional protein was made in homozygous mice. (J:17360)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 20 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Il6tm1Kopf
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Il6 Mutation:  37 strains or lines available
Original:  J:17360 Kopf M, et al., Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 1994 Mar 24;368(6469):339-42
All:  694 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory