Foxp3tm1(cre)Saka
Targeted Allele Detail
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Symbol: |
Foxp3tm1(cre)Saka |
Name: |
forkhead box P3; targeted mutation 1, Shimon Sakaguchi |
MGI ID: |
MGI:3812203 |
Synonyms: |
FIC, Fox-IRES-Cre, Foxp3IRES-Cre |
Gene: |
Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
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Alliance: |
Foxp3tm1(cre)Saka page
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Germline Transmission: |
Earliest citation of germline transmission:
J:140085
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
BALB/c
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Foxp3tm1(cre)Saka expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: An IRES-cre cassette and a frt-flanked neomycin resistance marker were placed into the last exon of the gene immediately after the TGA stop codon. Hemizygous male mice had slightly lower amounts of the FoxP3 gene product than controls, as determined by flow cytometry on freshly isolated lymphocytes. Crossing with cre-reporter transgenic mice demonstrates that cre expression was confined to about 15% of CD4+ T cells and ~1.5% of CD8+ T cells.
(J:140085)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Foxp3
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Foxp3 Mutation: |
55 strains or lines available
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Original: |
J:140085 Wing K, et al., CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008 Oct 10;322(5899):271-5 |
All: |
29 reference(s) |
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