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Targeted Allele Detail
Symbol: Socs1tm1Ayos
Name: suppressor of cytokine signaling 1; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:3778686
Synonyms: SOCS1fl
Gene: Socs1  Location: Chr16:10601672-10603400 bp, - strand  Genetic Position: Chr16, 5.81 cM
Alliance: Socs1tm1Ayos page
Germline Transmission:  Earliest citation of germline transmission: J:132905
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted in exon 2 downstream of the coding region and an additional loxP site was inserted downstream of exon 1. (J:132905)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Socs1 Mutation:  29 strains or lines available
Original:  J:132905 Tanaka K, et al., Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads. J Immunol. 2008 Mar 15;180(6):3746-56
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory