Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Ayos mutation
(1 available);
any
Socs1 mutation
(29 available)
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normal phenotype
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• most mice appear normal until the age of 4 months
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immune system
integument
vision/eye
hematopoietic system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Ayos mutation
(1 available);
any
Socs1 mutation
(29 available)
Tg(Lck-cre)1Jtak mutation
(3 available)
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immune system
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• IL-17 producing CD4+ T cells differentiated in vitro and induced with IL-6 and TGF-beta with the anti-TCR antibody results in stronger induction of IFN-gamma producing cells and a marked reduction of IL-17 producing cells in contrast to similarly treated wild-type cells
• CD4+ T cells preferentially differentiate into Th1 cells and not Th17 unlike wild-type cells
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• CD4+ T cells are resistant to the suppressive effects of TGF-beta on IGN-gamma production unlike wild-type cells
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• mice are less susceptible to experimental autoimmune encephalomyelitis (EAE) and produce less IL-17 following EAE compared to wild-type mice
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hematopoietic system
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• IL-17 producing CD4+ T cells differentiated in vitro and induced with IL-6 and TGF-beta with the anti-TCR antibody results in stronger induction of IFN-gamma producing cells and a marked reduction of IL-17 producing cells in contrast to similarly treated wild-type cells
• CD4+ T cells preferentially differentiate into Th1 cells and not Th17 unlike wild-type cells
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• CD4+ T cells are resistant to the suppressive effects of TGF-beta on IGN-gamma production unlike wild-type cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Ayos mutation
(1 available);
any
Socs1 mutation
(29 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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• mice die by 50 days of age of diseases similar to those observed in other Socs1 null mice
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immune system
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• mice exhibit decreased numbers of CD4+ T cells in the thymus and spleen compared to in wild-type mice
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• mice exhibit increased numbers of CD8+ T cells compared to in wild-type mice
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hematopoietic system
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• mice exhibit decreased numbers of CD4+ T cells in the thymus and spleen compared to in wild-type mice
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• mice exhibit increased numbers of CD8+ T cells compared to in wild-type mice
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