Cadpstm1.1Tfr/Cadpstm1.2Tfr
Ptf1atm1.1(cre)Cvw/Ptf1a+
B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr
|
abnormal cerebellar molecular layer |
J:204664
|
|
abnormal paired-pulse inhibition |
J:204664
|
|
abnormal synaptic bouton morphology |
J:204664
|
|
abnormal synaptic vesicle number |
J:204664
|
|
decreased excitatory postsynaptic current amplitude |
J:204664
|
|
normal
nervous system phenotype |
J:204664
|
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
|
decreased tumor-free survival time |
J:116130
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:116130
|
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N
|
decreased tumor-free survival time |
J:116130
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:116130
|
|
increased tumor incidence |
J:116130
|
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
|
decreased tumor-free survival time |
J:116130
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:116130
|
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N
|
decreased tumor-free survival time |
J:116130
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:116130
|
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
|
normal
nervous system phenotype |
J:243947
|
Etn2Sd/Etn2+
Ptf1a/Ptf1aostm1Kymm/Ptf1a+
involves: C57BL/6
|
abnormal skeleton morphology |
J:195133
|
|
abnormal tail morphology |
J:195133
|
|
absent pancreas |
J:195133
|
Etn2Sd/Etn2+
Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a+
involves: C57BL/6
|
short tail |
J:195133
|
|
short vertebral column |
J:195133
|
Etn2Sd/Etn2+
Ptf1a/Ptf1aostm3(CAG-Ptf1aos)Kymm/Ptf1a+
involves: C57BL/6
|
no abnormal phenotype detected |
J:195133
|
Etn2Sd/Etn2Sd
Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a/Ptf1aostm2(Ptf1a)Kymm
involves: C57BL/6
|
abnormal anus morphology |
J:195133
|
|
abnormal nucleus pulposus morphology |
J:195133
|
|
absent tail |
J:195133
|
|
decreased body length |
J:195133
|
|
normal
endocrine/exocrine gland phenotype |
J:195133
|
|
short vertebral column |
J:195133
|
Etn2Sd/Etn2Sd
Ptf1a/Ptf1aostm3(CAG-Ptf1aos)Kymm/Ptf1a/Ptf1aostm3(CAG-Ptf1aos)Kymm
involves: C57BL/6
|
no abnormal phenotype detected |
J:195133
|
Fat3tm1.1Good/Fat3tm1.2Good
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
|
abnormal retina neuronal layer morphology |
J:176668
|
Fat3tm1.2Good/Fat3tm1.2Good
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(CAG-Bgeo/GFP)21Lbe/0
involves: 129S1/Sv * 129X1/SvJ
|
abnormal amacrine cell morphology |
J:176668
|
|
abnormal retina neuronal layer morphology |
J:176668
|
Gad1tm2Oba/Gad1tm2Oba
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ
|
abnormal gait |
J:134497
|
|
abnormal inhibitory postsynaptic currents |
J:134497
|
|
abnormal nervous system morphology |
J:134497
|
|
normal
craniofacial phenotype |
J:134497
|
|
normal
endocrine/exocrine gland phenotype |
J:134497
|
|
normal
homeostasis/metabolism phenotype |
J:134497
|
|
impaired coordination |
J:134497
|
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras2)12Hev/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
|
increased pancreas tumor incidence |
J:184378
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:184378
|
|
increased susceptibility to injury |
J:184378
|
|
pancreatic acinar-to-ductal metaplasia |
J:184378
|
|
small pancreas |
J:184378
|
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras2)12Hev/0
Trp53tm1Tyj/Trp53+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
|
increased pancreatic ductal adenocarcinoma incidence |
J:184378
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:184378
|
|
increased susceptibility to injury |
J:184378
|
|
premature death |
J:184378
|
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras*G12D)#Rdp/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
|
increased pancreatic ductal adenocarcinoma incidence |
J:186194
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:186194
|
|
pancreatic acinar-to-ductal metaplasia |
J:186194
|
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras*G12D)#Rdp/0
Trp53tm1Brn/Trp53+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
|
increased pancreatic ductal adenocarcinoma incidence |
J:186194
|
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras*G12D)#Rdp/0
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
|
increased pancreatic ductal adenocarcinoma incidence |
J:186194
|
Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J
|
increased pancreatic ductal adenocarcinoma incidence |
J:140423
|
|
premature death |
J:140423
|
Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S6/SvEvTac * C57BL/6J
|
increased incidence of induced tumors |
J:140423
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:140423
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:140423
|
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptf1atm1(cre)Cvw/Ptf1atm2Macd
involves: 129
|
abnormal pancreas development |
J:125691
|
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss
|
abnormal digestive system development |
J:78710
|
|
abnormal pancreas development |
J:78710
|
|
absent pancreatic acini |
J:78710
|
|
increased retina ganglion cell number |
J:115271
|
Gt(ROSA)26Sortm1Sor/?
Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
involves: 129S4/SvJaeSor
|
abnormal retina layer morphology |
J:119184
|
|
abnormal retina neuronal layer morphology |
J:119184
|
|
absent amacrine cells |
J:119184
|
|
absent retina inner plexiform layer |
J:119184
|
|
neonatal lethality, complete penetrance |
J:119184
|
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae * 129S6/SvEvTac
|
normal
endocrine/exocrine gland phenotype |
J:197054
|
|
normal
neoplasm |
J:197054
|
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S6/SvEvTac
|
normal
endocrine/exocrine gland phenotype |
J:197054
|
|
normal
neoplasm |
J:197054
|
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S6/SvEvTac
|
enlarged pancreas |
J:197054
|
|
increased carcinoma incidence |
J:197054
|
|
increased pancreas weight |
J:197054
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:197054
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:197054
|
|
pancreatic acinar-to-ductal metaplasia |
J:197054
|
Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: C57BL/6
|
normal
endocrine/exocrine gland phenotype |
J:197054
|
|
normal
neoplasm |
J:197054
|
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm2Tyj
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129P2/OlaHsd * 129S4/SvJae
|
increased pancreatic ductal adenocarcinoma incidence |
J:197054
|
Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
|
increased metastatic potential |
J:116129
|
|
increased pancreas tumor incidence |
J:116129
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:116129
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:116129
|
|
premature death |
J:116129
|
Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2
|
abnormal duodenum morphology |
J:116129
|
|
abnormal hepatic portal vein morphology |
J:116129
|
|
abnormal hepatic portal vein thrombosis |
J:116129
|
|
dilated gallbladder |
J:116129
|
|
distended abdomen |
J:116129
|
|
enlarged spleen |
J:116129
|
|
hemorrhagic ascites |
J:116129
|
|
hepatic necrosis |
J:116129
|
|
increased metastatic potential |
J:116129
|
|
increased pancreas tumor incidence |
J:116129
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:116129
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:116129
|
|
jaundice |
J:116129
|
|
paralysis |
J:116129
|
|
premature death |
J:116129
|
|
weight loss |
J:116129
|
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw
|
increased metastatic potential |
J:138959
|
|
increased pancreas tumor incidence |
J:138959
|
|
increased pancreas weight |
J:138959
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:138959
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:138959
|
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
|
abnormal pancreatic acinar cell morphology |
J:262746
|
|
enlarged pancreas |
J:87973
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:87973,
J:116130
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:262746
|
|
increased tumor incidence |
J:87973
|
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
|
increased pancreatic intraepithelial neoplasia incidence |
J:116129
|
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MUC1)79.24Gend/0
B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend
|
decreased metastatic potential |
J:138959
|
|
increased pancreas tumor incidence |
J:138959,
J:234412
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:138959
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:138959,
J:234412
|
Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae
|
abnormal pancreas morphology |
J:197054
|
|
normal
neoplasm |
J:197054
|
Krastm4Tyj/Kras+
Raf1tm2Bacc/Raf1tm2Bacc
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129P2/OlaHsd * 129S4/SvJae
|
increased pancreatic ductal adenocarcinoma incidence |
J:197054
|
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N
|
decreased tumor-free survival time |
J:116130
|
|
increased pancreatic ductal adenocarcinoma incidence |
J:116130
|
|
increased tumor incidence |
J:116130
|
|
pancreas cyst |
J:116130
|
Krastm4Tyj/Kras+
Tg(Erbb2*)#Maed/0
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
|
abnormal pancreatic acinar cell morphology |
J:262746
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:262746
|
Krastm4Tyj/Krastm4Tyj
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae
|
increased pancreatic intraepithelial neoplasia incidence |
J:162125
|
Notch1tm1Agt/Notch1tm1Agt
Notch2tm1Frad/Notch2tm1Frad
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129 * BALB/cJ
|
abnormal branching involved in pancreas development |
J:139250
|
|
abnormal endocrine pancreas morphology |
J:139250
|
|
abnormal pancreas development |
J:139250
|
|
abnormal pancreatic acinus morphology |
J:139250
|
|
abnormal pancreatic bud formation |
J:139250
|
|
decreased pancreatic islet number |
J:139250
|
|
small pancreas |
J:139250
|
Pgbd5tm1.1Aken/Pgbd5tm1.2Aken
Ptch1tm1Bjw/Ptch1tm1Bjw
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW
|
increased medulloblastoma incidence |
J:346387
|
Pgbd5tm1.2Aken/Pgbd5tm1.2Aken
Ptch1tm1Bjw/Ptch1tm1Bjw
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW
|
decreased classified tumor incidence |
J:346387
|
|
increased tumor-free survival time |
J:346387
|
Ptf1atm1(cre)Hnak/Ptf1a+
Rbpjtm1Rsch/Rbpjtm1Rsch
involves: 129X1/SvJ
|
abnormal digestion |
J:139250
|
|
abnormal pancreas development |
J:139250
|
|
abnormal pancreas morphology |
J:139250
|
|
abnormal pancreatic alpha cell differentiation |
J:139250
|
|
decreased pancreatic acinar cell number |
J:139250
|
|
decreased pancreatic islet number |
J:139250
|
|
disorganized pancreatic islets |
J:139250
|
|
increased pancreatic alpha cell number |
J:139250
|
|
postnatal growth retardation |
J:139250
|
|
postnatal lethality, complete penetrance |
J:139250
|
|
small pancreas |
J:139250
|
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
|
abnormal pancreas development |
J:116129
|
Ptf1atm1.1(cre)Cvw/Ptf1a+
Smad4tm1Rdp/Smad4tm1Rdp
involves: 129 * FVB/N
|
normal
endocrine/exocrine gland phenotype |
J:116130
|
Ptf1atm1.1(cre)Cvw/Ptf1a+
Robo3tm1.1Ache/Robo3tm1.1Ache
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
|
abnormal brain commissure morphology |
J:158918
|
|
abnormal innervation |
J:158918
|
|
abnormal motor coordination/balance |
J:158918
|
|
ataxia |
J:158918
|
|
impaired coordination |
J:158918
|
Ptf1atm1.1(cre)Cvw/Ptf1a+
Sec24ctm1c(EUCOMM)Wtsi/Sec24ctm1c(EUCOMM)Wtsi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
|
normal
endocrine/exocrine gland phenotype |
J:232065
|
|
normal
growth/size/body region phenotype |
J:232065
|
|
normal
homeostasis/metabolism phenotype |
J:232065
|
Ptf1atm1.1(cre)Cvw/CbllTg(Alb-KL)7-2Mhos
involves: C57BL/6
|
abnormal GABAergic neuron morphology |
J:100997
|
|
abnormal Purkinje cell differentiation |
J:100997
|
Rbpjtm1Hon/Rbpjtm1.1Hon
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Ptf1atm2(cre/ESR1)Cvw/Ptf1a+
involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac
|
normal
endocrine/exocrine gland phenotype |
J:180310
|
Relatm1Rsch/Relatm1Rsch
Ptf1atm1(cre)Hnak/?
involves: C57BL/6
|
abnormal interleukin level |
J:122194
|
|
abnormal response/metabolism to endogenous compounds |
J:122194
|
|
abnormal tumor necrosis factor level |
J:122194
|
|
increased susceptibility to xenobiotic induced morbidity/mortality |
J:122194
|
|
lung inflammation |
J:122194
|
|
pancreas inflammation |
J:122194
|
Sbdstm1Jrom/Sbdstm3.1Jrom
Ptf1atm1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
|
abnormal pancreatic islet size |
J:189357
|
|
decreased body length |
J:189357
|
|
decreased circulating amylase level |
J:189357
|
|
impaired glucose tolerance |
J:189357
|
|
pancreas hypoplasia |
J:189357
|
|
postnatal growth retardation |
J:189357
|
|
small pancreas |
J:189357
|
Sbdstm2.1Jrom/Sbdstm3.1Jrom
Ptf1atm1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ
|
abnormal pancreatic islet size |
J:189357
|
|
decreased body length |
J:189357
|
|
decreased circulating amylase level |
J:189357
|
|
normal
embryo phenotype |
J:189357
|
|
pancreas lipomatosis |
J:189357
|
|
pancreatic acinar hypoplasia |
J:189357
|
|
postnatal growth retardation |
J:189357
|
|
small pancreas |
J:189357
|
Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ
|
normal
endocrine/exocrine gland phenotype |
J:229184
|
Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0
involves: 129S1/Sv * 129X1/SvJ * CD-1
|
abnormal pancreas morphology |
J:229184
|
|
abnormal pancreatic acinar cell morphology |
J:229184
|
|
abnormal pancreatic duct morphology |
J:229184
|
|
abnormal pancreatic islet morphology |
J:229184
|
|
chronic pancreas inflammation |
J:229184
|
|
dilated pancreatic duct |
J:229184
|
|
enlarged pancreas |
J:229184
|
|
increased pancreatic intraepithelial neoplasia incidence |
J:229184
|
|
pancreas cyst |
J:229184
|
|
pancreas fibrosis |
J:229184
|
|
pancreatic acinar-to-ductal metaplasia |
J:229184
|
Tg(Erbb2*)#Maed/0
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
normal
endocrine/exocrine gland phenotype |
J:262746
|
Tg(Etn2*,Ptf1aos,Ptf1a)#Kymm/0
involves: C57BL/6
|
short tail |
J:195133
|
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