Pgbd5^tm1.1Aken
Targeted Allele Detail

Summary

• Symbol: Pgbd5^tm1.1Aken
• Name: piggyBac transposable element derived 5; targeted mutation 1.1, Alex Kentsis
• MGI ID: MGI:7334716
• Synonyms: Pgdb5^fl
• Gene: Pgbd5 Location: Chr8:125095788-125161230 bp, - strand Genetic Position: Chr8, 72.65 cM
• Alliance: Pgbd5^tm1.1Aken page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:346387
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting cassette is composed of an FRT site, lacZ sequence, a loxP site, a neomycin resistance gene, a second FRT site, and a second loxP site inserted upstream of exon 4. A third loxP site is inserted downstream of exon 4. FLP-mediated recombination removed the lacZ and neo cassette. (J:346387)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pgbd5 Mutation: 33 strains or lines available

References

• Original: J:346387 Yamada M, et al., Childhood cancer mutagenesis caused by transposase-derived PGBD5. Sci Adv. 2024 Mar 22;10(12):eadn4649
• All: 2 reference(s)