Rbpj^tm1.1Hon
Targeted Allele Detail

Summary

• Symbol: Rbpj^tm1.1Hon
• Name: recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1.1, Tasuku Honjo
• MGI ID: MGI:3807508
• Synonyms: Rpbj^delta
• Gene: Rbpj Location: Chr5:53713121-53814787 bp, + strand Genetic Position: Chr5, 29.37 cM, cytoband C1-C3
• Alliance: Rbpj^tm1.1Hon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130251
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted to flank exon 6, which encodes the DNA binding domain, and exon 7. In addition, a neomycin resistance gene was inserted between exon 7 and the 3' loxP site. Cre-mediated recombination generated a null allele. (J:130251)

Expression

In Mice Carrying this Mutation:	35 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbpj Mutation: 193 strains or lines available

References

• Original: J:130251 Hori K, et al., A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev. 2008 Jan 15;22(2):166-78
• All: 13 reference(s)