Phenotypes associated with this allele
endocrine/exocrine glands
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N |
• tamoxifen-treated mice exhibit normal proliferation of YFP+ acinar cells
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endocrine/exocrine glands
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N |
• tamoxifen-treated mice exhibit normal pancreatic ductal morphology and pancreata mass
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• tamoxifen-treated mice exhibit a decrease in YFP+ centroacinar cells compared with control mice
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• tamoxifen-treated mice exhibit an increase in YFP+ acinar cells compared with control mice
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• tamoxifen-treated mice exhibit a rapid transformation of YFP+ centroacinar cells into acinar cells compared with control mice
• however, tamoxifen-treated mice exhibit normal centroacinar and acinar cells proliferation and apoptosis
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digestive/alimentary system
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• tamoxifen-treated mice exhibit a decrease in YFP+ centroacinar cells compared with control mice
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• tamoxifen-treated mice exhibit an increase in YFP+ acinar cells compared with control mice
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respiratory system
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• at E18.5, the respiratory epithelium was populated almost exclusively by Foxj1-expressing ciliated cells, unlike in control lungs where ciliated cells were interspersed with secretory Clara cells
• at E18.5, Ki67 labeling was dramatically reduced in large, medium and small airways, suggesting a severe decrease in epithelial cell proliferation relative to control lungs
• however, goblet cell fate was not lost, as shown by PAS and Alcian Blue staining of tracheal sections at birth (P0)
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• no secretory Clara cells were detected at E18.5, as determined by specific marker analysis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpjtm1.1Hon mutation
(1 available);
any
Rbpj mutation
(193 available)
Rbpjtm1Hon mutation
(2 available);
any
Rbpj mutation
(193 available)
Tg(Pax7-cre/ERT2)1Cbm mutation
(0 available)
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nervous system
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• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons and an increased in the number of dILB neurons compared to in wild-type mice
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• there is a decrease in the thickness of the progenitor zone in the neural tube of E13.5 embryos when tamoxifen is given at E10.5
• tamoxifen induction at E10.5 leads to about a 50% reduction in dILA neurons in newborns and about a 50% increase in dILB neurons
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• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons compared to in wild-type mice
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• following treatment with tamoxifen, mice exhibit an increased in the number of dILB neurons compared to in wild-type mice
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• at E13.5 following treatment with tamoxifen, the progenitor domain is reduced compared to in wild-type mice
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embryo
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• there is a decrease in the thickness of the progenitor zone in the neural tube of E13.5 embryos when tamoxifen is given at E10.5
• tamoxifen induction at E10.5 leads to about a 50% reduction in dILA neurons in newborns and about a 50% increase in dILB neurons
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cellular
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• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons and an increased in the number of dILB neurons compared to in wild-type mice
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Analysis Tools
