Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rbpjtm1.1Hon targeted mutation 1.1, Tasuku Honjo MGI:3807508 |
||||||||||||||||||||||||||||
| Summary |
6 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• retinas exhibit elevated vessel branching at P5
|
|
• retinas exhibit elevated vessel branching at P5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen-treated mice exhibit normal pancreatic ductal morphology and pancreata mass
|
|
• tamoxifen-treated mice exhibit a decrease in YFP+ centroacinar cells compared with control mice
|
|
• tamoxifen-treated mice exhibit an increase in YFP+ acinar cells compared with control mice
|
|
• tamoxifen-treated mice exhibit a rapid transformation of YFP+ centroacinar cells into acinar cells compared with control mice
• however, tamoxifen-treated mice exhibit normal centroacinar and acinar cells proliferation and apoptosis
|
|
• tamoxifen-treated mice exhibit a decrease in YFP+ centroacinar cells compared with control mice
|
|
• tamoxifen-treated mice exhibit an increase in YFP+ acinar cells compared with control mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen-treated mice exhibit normal proliferation of YFP+ acinar cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at E18.5, the respiratory epithelium was populated almost exclusively by Foxj1-expressing ciliated cells, unlike in control lungs where ciliated cells were interspersed with secretory Clara cells
• at E18.5, Ki67 labeling was dramatically reduced in large, medium and small airways, suggesting a severe decrease in epithelial cell proliferation relative to control lungs
• however, goblet cell fate was not lost, as shown by PAS and Alcian Blue staining of tracheal sections at birth (P0)
|
|
• no secretory Clara cells were detected at E18.5, as determined by specific marker analysis
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons and an increased in the number of dILB neurons compared to in wild-type mice
|
|
• there is a decrease in the thickness of the progenitor zone in the neural tube of E13.5 embryos when tamoxifen is given at E10.5
• tamoxifen induction at E10.5 leads to about a 50% reduction in dILA neurons in newborns and about a 50% increase in dILB neurons
|
|
• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons compared to in wild-type mice
|
|
• following treatment with tamoxifen, mice exhibit an increased in the number of dILB neurons compared to in wild-type mice
|
|
• at E13.5 following treatment with tamoxifen, the progenitor domain is reduced compared to in wild-type mice
|
|
• there is a decrease in the thickness of the progenitor zone in the neural tube of E13.5 embryos when tamoxifen is given at E10.5
• tamoxifen induction at E10.5 leads to about a 50% reduction in dILA neurons in newborns and about a 50% increase in dILB neurons
|
|
• following treatment with tamoxifen, mice exhibit a reduction in the number of dILA neurons and an increased in the number of dILB neurons compared to in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• retinas exhibit enhanced elevation in vessel branching at P5 than single Rbpj heterozygotes
|
|
• retinas show greater extravascular fibrinogen staining and extravasation of perfused sulfo-NHS-LC-biotin, indicating greater impaired vascular integrity than single Eogt homozygotes
|
|
• retinas exhibit enhanced elevation in vessel branching at P5 than single Rbpj heterozygotes
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
