Robo3^tm1.1Ache
Targeted Allele Detail

Summary

• Symbol: Robo3^tm1.1Ache
• Name: roundabout guidance receptor 3; targeted mutation 1.1, Alain Chedotal
• MGI ID: MGI:4441335
• Synonyms: Robo3^cko, Robo3^lox
• Gene: Robo3 Location: Chr9:37327341-37344730 bp, - strand Genetic Position: Chr9, 20.76 cM, cytoband B
• Alliance: Robo3^tm1.1Ache page

The structure of the inferior olivary nucleus is disorganized in Robo3^tm1.1Ache/Robo3^tm1.1Ache Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ mice

Show the 7 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158918
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An frt and loxP flanked neo cassette was inserted upstream of exon 12 and a loxP site was inserted downstream of exon 14 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 12 - 14 floxed. (J:158918)

Generation of a Robo3^tm1.1Ache allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Robo3 Mutation: 71 strains or lines available

References

• Original: J:158918 Renier N, et al., Genetic dissection of the function of hindbrain axonal commissures. PLoS Biol. 2010;8(3):e1000325
• All: 11 reference(s)