Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1tm2(cre)Apie mutation
(1 available);
any
Dbx1 mutation
(25 available)
Robo3tm1.1Ache mutation
(0 available);
any
Robo3 mutation
(71 available)
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mortality/aging
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• mice do not survive after birth
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nervous system
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• mice exhibit reduced biocytin stained commissural interneurons in the pre-Botzinger complex compared with wild-type mice
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• mice exhibit reduced biocytin stained commissural interneurons in the pre-Botzinger complex compared with wild-type mice
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• mice exhibit de-synchronization of rhythmic activity in the left and right pre-Botzinger complex compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1atm1.1(cre)Cvw mutation
(1 available);
any
Ptf1a mutation
(30 available)
Robo3tm1.1Ache mutation
(0 available);
any
Robo3 mutation
(71 available)
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Ataxic gait in Robo3tm1.1Ache/Robo3tm1.1Ache Ptf1atm1.1(cre)Cvw/Ptf1a+ mice
nervous system
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• severe impairment of the interolivary commissure
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• only about 1/3 of inferior olivary neurons project contralaterally compared to wild-type controls where all neurons project contralaterally
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behavior/neurological
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• in an Erasmus ladder test step time and overall walking pattern are severely abnormal
• impairment is more severe than that of Grid2Lc mice
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• decrease in latency to fall of a rotarod
• impairment is more severe than that of Grid2Lc mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2tm2(cre)Pch mutation
(2 available);
any
Egr2 mutation
(31 available)
Robo3tm1.1Ache mutation
(0 available);
any
Robo3 mutation
(71 available)
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Reduced internuclear commissure in Robo3tm1.1Ache/Robo3tm1.1Ache Egr2tm2(cre)Pch/Egr2+ mice
nervous system
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• at E11 - E12, a severe reduction of commissural projections in r3 and r5 is seen
• at E15 and in newborns, virtually no axons are found to cross the midline at the level of the abducens nuclei
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• globular bushy cell projections from the anteroventral cochlear nucleus to the principal cells of the median nucleus of the trapezoid body are exclusively ipsilateral
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behavior/neurological
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• impairment in horizontal visual vestibuloocular reflex (VVOR) but not in vertical VVOR
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• impairment in horizontal OKR but not in vertical OKR
• defects occur predominantly in the low frequency range
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• impairment in horizontal VOR but not in vertical VOR
• defects in VOR are more predominant at high frequencies
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hearing/vestibular/ear
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• impairment in horizontal VOR but not in vertical VOR
• defects in VOR are more predominant at high frequencies
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• 3 rather than 4 waves are present ipsilaterally and the third wave has a longer latency and is not followed by any identifiable wave
• the appearance of contralateral wave IVc is delayed compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2tm2(cre)Pch mutation
(2 available);
any
Egr2 mutation
(31 available)
Robo3tm1.1Ache mutation
(0 available);
any
Robo3 mutation
(71 available)
Tg(Mnx1-EGFP)#Tmj mutation
(0 available)
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nervous system
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• at E14, the abducens motor nucleus is closer to the floor plate and abnormally shaped
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Analysis Tools