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Egr2tm2(cre)Pch
Targeted Allele Detail
Summary
Symbol: Egr2tm2(cre)Pch
Name: early growth response 2; targeted mutation 2, Patrick Charnay
MGI ID: MGI:1931056
Synonyms: Egr2::Cre, KCN, Krox-20Cre, Krox-20-Cre, Krox20/Cre
Gene: Egr2  Location: Chr10:67371305-67378018 bp, + strand  Genetic Position: Chr10, 34.96 cM, cytoband B5
Alliance: Egr2tm2(cre)Pch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60874
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Egr2tm2(cre)Pch expression driven by 1 gene
 
Mutation detailsDNA sequences corresponding to the two alternative initiation codons were replaced by an nls-Cre gene, followed by a neomycin cassette. Expression was expected in the hindbrain, bones and the peripheral nervous system as well as both the male and female germlines. (J:60874)
Inheritance:    Recessive
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Egr2 (mouse)
Summary of all recombinase alleles driven by Egr2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
Tumor Data
List all tumor models in MMHCdb carrying Egr2tm2(cre)Pch
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Egr2 Mutation:  35 strains or lines available
References
Original:  J:60874 Voiculescu O, et al., Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system. Genesis. 2000 Feb;26(2):123-6
All:  87 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory