Cdh1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8346384
Gene symbol:	Cdh1
Gene name:	cadherin 1

Antibody:	Anti-E-Cadherin (610181; Clone 36)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

1A left ©

Specimen 1A: embryonic day 9.75 (more

)
Note: Triple labeled: magenta - Cdh1; green - Lats1 (assay MGI:8346371) and Lats2 (assay MGI:8346382); red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS15: pancreas primordium	Present		1A left

1C ©

Specimen 1C: postnatal day 1 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: white - Cdh1; red - Gcg (assay MGI:8346997); green - Ins1 (assay MGI:8347766) and Ins2 (assay MGI:8347767).

Structure	Level	Pattern	Image	Note
TS27: pancreas	Present		1C

1G ©

Specimen 1G: postnatal day 1; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: white - Cdh1; red - Gcg (assay MGI:8346997); green - Ins1 (assay MGI:8347766) and Ins2 (assay MGI:8347767).

Structure	Level	Pattern	Image	Note
TS27: pancreas	Present		1G

1K ©

Specimen 1K: embryonic day 15.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: white - Cdh1; red - Gcg (assay MGI:8346997).

Structure	Level	Pattern	Image	Note
TS23: pancreas	Present		1K

1L ©

Specimen 1L: embryonic day 15.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: white - Cdh1; red - Gcg (assay MGI:8346997).

Structure	Level	Pattern	Image	Note
TS23: pancreas	Present		1L

1M left ©

Specimen 1M: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: white - Cdh1; red - Gcg (assay MGI:8346997); green - Yap1 (assay MGI:8347770).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		1M left

1N left ©

Specimen 1N: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: white - Cdh1; red - Gcg (assay MGI:8346997); green - Yap1 (assay MGI:8347770).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		1N left

1O left ©

Specimen 1O: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0, Wwtr1^tm1.1Eno/Wwtr1⁺, Yap1^tm1.1Eno/Yap1^tm1.1Eno (more

)
Note: Conditional mutant. Triple labeled: white - Cdh1; red - Gcg (assay MGI:8346997); green - Yap1 (assay MGI:8347770).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		1O left

2A ©

Specimen 2A: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: red - Cdh1; green - Vim (assay MGI:8348238).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Strong		2A

2B ©

Specimen 2B: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: red - Cdh1; green - Vim (assay MGI:8348238).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Strong		2B	The mutant epithelium retained relatively strong CDH1 expression.

2E ©

Specimen 2E: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Tagln (assay MGI:8351282).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		2E

2I ©

Specimen 2I: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Tagln (assay MGI:8351282).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		2I

5A ©

Specimen 5A: embryonic day 12.0 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Nfkb1 (assay MGI:8351665).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		5A

5B ©

Specimen 5B: embryonic day 12.0; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Nfkb1 (assay MGI:8351665).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		5B

5D ©

Specimen 5D: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: magenta - Cdh1; green - Nfkb1 (assay MGI:8351665); red - pHH3.

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		5D

5E ©

Specimen 5E: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: magenta - Cdh1; green - Nfkb1 (assay MGI:8351665); red - pHH3.

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		5E

S1A WT upper ©

Specimen S1A WT: embryonic day 15.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: white - Cdh1; green - Lats1 (assay MGI:8346371) and Lats2 (assay MGI:8346382).

Structure	Level	Pattern	Image	Note
TS23: pancreas	Present		S1A WT upper

S1A Lats1/2^PanKO upper ©

Specimen S1A Lats1/2^PanKO: embryonic day 15.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: white - Cdh1; green - Lats1 (assay MGI:8346371) and Lats2 (assay MGI:8346382).

Structure	Level	Pattern	Image	Note
TS23: pancreas	Present		S1A Lats1/2^PanKO upper

S1B WT upper ©

Specimen S1B WT E11.5: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Present		S1B WT upper	A progressive expansion of epithelial volume accompanied by complex branching morphogenesis was observed in wild type.

S1B Lats1/2^PanKO upper ©

Specimen S1B Lats1/2^PanKO E11.5: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Present		S1B Lats1/2^PanKO upper	At E11.5, there was an abrupt, transient expansion in pancreatic volume, but the mutant pancreas did not initiate branch formation.

S1B WT middle ©

Specimen S1B WT E12.0: embryonic day 12.0 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Present		S1B WT middle	A progressive expansion of epithelial volume accompanied by complex branching morphogenesis was observed in wild type.

S1B Lats1/2^PanKO middle ©

Specimen S1B Lats1/2^PanKO E12.0: embryonic day 12.0; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Present		S1B Lats1/2^PanKO middle	The mutant pancreas remained small and rounded.

S1B WT lower ©

Specimen S1B WT E12.5: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images.

Structure	Level	Pattern	Image	Note
TS20: pancreas epithelium	Present		S1B WT lower	A progressive expansion of epithelial volume accompanied by complex branching morphogenesis was observed in wild type.

S1B Lats1/2^PanKO lower ©

Specimen S1B Lats1/2^PanKO E12.5: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images.

Structure	Level	Pattern	Image	Note
TS20: pancreas epithelium	Present		S1B Lats1/2^PanKO lower	The mutant pancreas remained small and rounded.

S1D WT upper ©

Specimen S1D WT E11.5: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: green - Cdh1; magenta - Gcg (assay MGI:8346997) and Ins1 (assay MGI:8347766) and Ins2 (assay MGI:8347767); red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S1D WT upper

S1D Lats1/2^PanKO upper ©

Specimen S1D Lats1/2^PanKO E11.5: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: green - Cdh1; magenta - Gcg (assay MGI:8346997) and Ins1 (assay MGI:8347766) and Ins2 (assay MGI:8347767); red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S1D Lats1/2^PanKO upper

S1D WT lower ©

Specimen S1D WT E12.5: embryonic day 12.5 (more

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S1D WT lower

S1D Lats1/2^PanKO lower ©

Specimen S1D Lats1/2^PanKO E12.5: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: green - Cdh1; magenta - Gcg (assay MGI:8346997) and Ins1 (assay MGI:8347766) and Ins2 (assay MGI:8347767); red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S1D Lats1/2^PanKO lower

S1F left ©

S1F right ©

Specimen S1F: embryonic day 10.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: white - Cdh1; red - Gcg (assay MGI:8346997); green - Yap1 (assay MGI:8348237).

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium	Present		S1F right , S1F left

S1H left ©

S1H right ©

Specimen S1H: embryonic day 10.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. . Triple labeled: white - Cdh1; red - Gcg (assay MGI:8346997); green - Yap1 (assay MGI:8348237).

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium	Present		S1H right , S1H left

S1J WT upper ©

Specimen S1J WT: embryonic day 12.0 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Wwtr1 (assay MGI:8348239).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S1J WT upper

S1J Lats1/2^PanKO upper ©

Specimen S1J Lats1/2^PanKO: embryonic day 12.0; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Wwtr1 (assay MGI:8348239).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S1J Lats1/2^PanKO upper

S1K WT upper ©

Specimen S1K WT: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Yap1 (assay MGI:8348237).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S1K WT upper

S1K Lats1/2^PanKO upper ©

Specimen S1K Lats1/2^PanKO: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Yap1 (assay MGI:8348237).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S1K Lats1/2^PanKO upper

S2D WT ©

Specimen S2D WT: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: white - Cdh1; red - Muc1 (assay MGI:8346383); green - pHH3.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S2D WT

S2D Lats1/2/Yap1^PanKOTaz^Het ©

Specimen S2D Lats1/2/Yap1^PanKOTaz^Het: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0, Wwtr1^tm1.1Eno/Wwtr1⁺, Yap1^tm1.1Eno/Yap1^tm1.1Eno (more

)
Note: Conditional mutant. Triple labeled: white - Cdh1; red - Muc1 (assay MGI:8346383); green - pHH3.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S2D Lats1/2/Yap1^PanKOTaz^Het	Normal expression was detected in Lats1/2/Yap1<PanKO>Taz<Het> mice.

S2D Lats1/2^PanKO ©

Specimen S2D Lats1/2^PanKO: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: white - Cdh1; red - Muc1 (assay MGI:8346383); green - pHH3.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S2D Lats1/2^PanKO

S4A WT E11.5 ©

Specimen S4A WT E11.5: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images. Double labeled: green - Cdh1; red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S4A WT E11.5

S4A Lats1/2^PanKO E11.5 ©

Specimen S4A Lats1/2^PanKO E11.5: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images. Double labeled: green - Cdh1; red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S4A Lats1/2^PanKO E11.5

S4A WT E12.0 ©

Specimen S4A WT E12.0: embryonic day 12.0 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images. Double labeled: green - Cdh1; red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S4A WT E12.0

S4A Lats1/2^PanKO E12.0 ©

Specimen S4A Lats1/2^PanKO E12.0: embryonic day 12.0; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images. Double labeled: green - Cdh1; red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S4A Lats1/2^PanKO E12.0

S4A WT E12.5 ©

Specimen S4A WT E12.5: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images. Double labeled: green - Cdh1; red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S4A WT E12.5

S4A Lats1/2^PanKO E12.5 ©

Specimen S4A Lats1/2^PanKO E12.5: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images. Double labeled: green - Cdh1; red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S4A Lats1/2^PanKO E12.5

S5A WT ©

Specimen S5A WT: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Snai2 (assay MGI:8352316).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		S5A WT

S5A Lats1/2^PanKO ©

Specimen S5A Lats1/2^PanKO: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Snai2 (assay MGI:8352316).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		S5A Lats1/2^PanKO

S7C WT ©

Specimen S7C WT: embryonic day 13.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: red - Cdh1; green - Vnn1 (assay MGI:8351300).

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S7C WT

S7C Lats1/2^PanKO ©

Specimen S7C Lats1/2^PanKO: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: red - Cdh1; green - Vnn1 (assay MGI:8351300).

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S7C Lats1/2^PanKO

S8E WT lower ©

S8E WT upper ©

Specimen S8E WT: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Ptprc (assay MGI:8352881).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S8E WT lower , S8E WT upper

Specimen S8E Lats1/2^PanKO: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Ptprc (assay MGI:8352881).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S8E Lats1/2^PanKO lower , S8E Lats1/2^PanKO upper

S8G WT lower ©

S8G WT upper ©

Specimen S8G WT: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Ptprc (assay MGI:8352881).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		S8G WT upper , S8G WT lower

Specimen S8G Lats1/2^PanKO: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Ptprc (assay MGI:8352881).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		S8G Lats1/2^PanKO lower , S8G Lats1/2^PanKO upper

S9C WT row 2 ©

Specimen S9C WT E11.5: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: white - Cdh1; red - pHH3.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S9C WT row 2

Specimen S9C Lats1/2^PanKO E11.5: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: white - Cdh1; red - pHH3.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S9C Lats1/2^PanKO row 2

S9C WT row 3 ©

Specimen S9C WT E12.5: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: white - Cdh1; red - pHH3.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S9C WT row 3

Specimen S9C Lats1/2^PanKO E12.5: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: white - Cdh1; red - pHH3.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S9C Lats1/2^PanKO row 3

S9E WT row 1 ©

Specimen S9E WT E11.5: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Casp3 (assay MGI:8352886).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S9E WT row 1

Specimen S9E Lats1/2^PanKO E11.5: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Casp3 (assay MGI:8352886).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S9E Lats1/2^PanKO row 1

S9E WT row 2 ©

Specimen S9E WT E12.5: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Casp3 (assay MGI:8352886).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S9E WT row 2

Specimen S9E Lats1/2^PanKO E12.5: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Casp3 (assay MGI:8352886).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S9E Lats1/2^PanKO row 2

S9E WT row 3 ©

Specimen S9E WT E13.5: embryonic day 13.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Casp3 (assay MGI:8352886).

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S9E WT row 3

Specimen S9E Lats1/2^PanKO E13.5: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Casp3 (assay MGI:8352886).

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S9E Lats1/2^PanKO row 3

S9E WT row 4 ©

Specimen S9E WT E14.5: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: magenta - Cdh1; green - Casp3 (assay MGI:8352886).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		S9E WT row 4

Specimen S9E Lats1/2^PanKO E14.5: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: magenta - Cdh1; green - Casp3 (assay MGI:8352886).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present		S9E Lats1/2^PanKO row 4

Specimen S10A upper WT: embryonic day 13.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: white - Cdh1; green - Pecam1 (assay MGI:8352259); red - pHH3.

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S10A WT upper

Specimen S10A upper Lats1/2^PanKO: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: white - Cdh1; green - Pecam1 (assay MGI:8352259); red - pHH3.

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S10A Lats1/2^PanKO upper	Pecam1-positive endothelial cells failed to associate with Lats1/2<PanKO> Cdh1-positive cells.

Specimen S10A lower WT: embryonic day 13.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: white - Cdh1; green - Pecam1 (assay MGI:8352259); red - pHH3.

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S10A WT lower

Specimen S10A lower Lats1/2^PanKO: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: white - Cdh1; green - Pecam1 (assay MGI:8352259); red - pHH3.

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S10A Lats1/2^PanKO lower	Pecam1-positive endothelial cells failed to associate with Lats1/2<PanKO> Cdh1-positive cells.

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