Yap1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8348237
Gene symbol:	Yap1
Gene name:	yes-associated protein 1

Antibody:	anti-YAP (#4912)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

S1F left ©

S1F right ©

Specimen S1F: embryonic day 10.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: green - Yap1; white - Cdh1 (assay MGI:8346384); red - Gcg (assay MGI:8346997).

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium	Present		S1F right , S1F left	In WT pancreas nuclear YAP1 was present.

S1H left ©

S1H right ©

Specimen S1H: embryonic day 10.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: green - Yap1; white - Cdh1 (assay MGI:8346384); red - Gcg (assay MGI:8346997).

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium	Present		S1H left , S1H right	The Lats1/2<PanKO> pancreatic bud increased nuclear YAP1.

S1K WT lower ©

S1K WT upper ©

Specimen S1K WT: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Yap1; magenta - Cdh1 (assay MGI:8346384).

Structure	Cell Type	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	epithelial cell of pancreas	Present	Regionally restricted	S1K WT upper , S1K WT lower	Nuclear expression was detected in a subset of wild type epithelial cells.

Specimen S1K Lats1/2^PanKO: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Yap1; magenta - Cdh1 (assay MGI:8346384).

Structure	Cell Type	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	epithelial cell of pancreas	Present	Regionally restricted	S1K Lats1/2^PanKO upper , S1K Lats1/2^PanKO lower	Increased nuclear expression was detected in Lats1/2<PanKO> pancreas at E11.5.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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