Tagln Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8351282
Gene symbol:	Tagln
Gene name:	transgelin

Antibody:	anti-SM22 alpha (ab14106)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

2C ©

Specimen 2C: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Absent		2C

2D ©

Specimen 2D: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS20: pancreas epithelium	Absent		2D

2E ©

Specimen 2E: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Tagln; magenta - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Absent		2E

2G ©

Specimen 2G: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Present	Non-Uniform	2G	A mosaic expression pattern was found in the Lats1/2<PanKO> mutant.

2H ©

Specimen 2H: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present	Non-Uniform	2H	Lats1/2<PanKO> mutant cells lost many epithelial characteristics and increasingly expressed aberrant Tagln.

2I ©

Specimen 2I: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Tagln; magenta - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present	Non-Uniform	2I	Lats1/2<PanKO> mutant cells lost many epithelial characteristics and increasingly expressed aberrant Tagln.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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