Lats1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8346371
Gene symbol:	Lats1
Gene name:	large tumor suppressor

Antibody:	Anti-phospho-LATS1/2 (A8125)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

1A left ©

1A right ©

Specimen 1A: embryonic day 9.75 (more

)
Note: Triple labeled: green - Lats1 and Lats2; magenta - Cdh1 (assay MGI:8346384); red - Muc1 (assay MGI:8346383).

Structure	Level	Pattern	Image	Note
TS15: pancreas primordium	Present	Regionally restricted	1A right , 1A left	Staining was localized to the apical domains adjacent to mucin-1+ microlumens in the wild type pancreatic bud at embryonic day 9.75.

S1A WT lower ©

S1A WT upper ©

Specimen S1A WT: embryonic day 15.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Lats1 and Lats2; white - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS23: pancreas epithelium	Present	Regionally restricted	S1A WT lower , S1A WT upper	Expression was detected at the apical surface of mature lumens at E15.5.

Specimen S1A Lats1/2^PanKO: embryonic day 15.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Lats1 and Lats2; white - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS23: pancreas epithelium	Trace		S1A Lats1/2^PanKO upper , S1A Lats1/2^PanKO lower	Expression was nearly undetectable by E15.5 in Lats1/2<PanKO>.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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