Muc1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8346383
Gene symbol:	Muc1
Gene name:	mucin 1, transmembrane

Antibody:	anti-Muc1 (HM-1630-P)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

1A left ©

1A right ©

Specimen 1A: embryonic day 9.75 (more

)
Note: Triple labeled: red - Muc1; magenta - Cdh1 (assay MGI:8346384); green - Lats1 (assay MGI:8346371) and Lats2 (assay MGI:8346382).

Structure	Level	Pattern	Image	Note
TS15: pancreas primordium	Present	Regionally restricted	1A left , 1A right	Staining was localized to microlumens.

1D ©

Specimen 1D: postnatal day 1 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: red - Muc1; green - AMY.

Structure	Level	Pattern	Image	Note
TS27: pancreas	Present		1D

1E ©

Specimen 1E: postnatal day 1 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: red - Muc1; green - AMY.

Structure	Level	Pattern	Image	Note
TS27: pancreas	Present		1E

1H ©

Specimen 1H: postnatal day 1; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: red - Muc1; green - DBA.

Structure	Level	Pattern	Image	Note
TS27: pancreas	Present		1H

1I ©

Specimen 1I: postnatal day 1; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: red - Muc1; green - DBA.

Structure	Level	Pattern	Image	Note
TS27: pancreas	Ambiguous		1I

S1D WT upper ©

Specimen S1D WT E11.5: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: red - Muc1; green - Cdh1 (assay MGI:8346384); magenta - Gcg (assay MGI:8346997) and Ins1 (assay MGI:8347766) and Ins2 (assay MGI:8347767).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S1D WT upper

S1D Lats1/2^PanKO upper ©

Specimen S1D Lats1/2^PanKO E11.5: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: red - Muc1; green - Cdh1 (assay MGI:8346384); magenta - Gcg (assay MGI:8346997) and Ins1 (assay MGI:8347766) and Ins2 (assay MGI:8347767).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Ambiguous		S1D Lats1/2^PanKO upper

S1D WT lower ©

Specimen S1D WT E12.5: embryonic day 12.5 (more

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S1D WT lower

S1D Lats1/2^PanKO lower ©

Specimen S1D Lats1/2^PanKO E12.5: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: red - Muc1; green - Cdh1 (assay MGI:8346384); magenta - Gcg (assay MGI:8346997) and Ins1 (assay MGI:8347766) and Ins2 (assay MGI:8347767).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Weak		S1D Lats1/2^PanKO lower

S2D WT ©

Specimen S2D WT: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: red - Muc1; white - Cdh1 (assay MGI:8346384); green - pHH3.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present	Non-Uniform	S2D WT

S2D Lats1/2/Yap1^PanKOTaz^Het ©

Specimen S2D Lats1/2/Yap1^PanKOTaz^Het: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0, Wwtr1^tm1.1Eno/Wwtr1⁺, Yap1^tm1.1Eno/Yap1^tm1.1Eno (more

)
Note: Conditional mutant. Triple labeled: red - Muc1; white - Cdh1 (assay MGI:8346384); green - pHH3.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present	Non-Uniform	S2D Lats1/2/Yap1^PanKOTaz^Het	Normal expression was detected in Lats1/2/Yap1<PanKO>Taz<Het> mice.

S2D Lats1/2^PanKO ©

Specimen S2D Lats1/2^PanKO: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: red - Muc1; white - Cdh1 (assay MGI:8346384); green - pHH3.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Ambiguous		S2D Lats1/2^PanKO

S4A WT E11.5 ©

Specimen S4A WT E11.5: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images. Double labeled: red - Muc1; green - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present	Regionally restricted	S4A WT E11.5	Staining was localized to microlumens.

S4A Lats1/2^PanKO E11.5 ©

Specimen S4A Lats1/2^PanKO E11.5: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images. Double labeled: red - Muc1; green - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		S4A Lats1/2^PanKO E11.5

S4A WT E12.0 ©

Specimen S4A WT E12.0: embryonic day 12.0 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images. Double labeled: red - Muc1; green - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present	Regionally restricted	S4A WT E12.0	Staining was localized to microlumens.

Specimen S4A Lats1/2^PanKO E12.0: embryonic day 12.0; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images. Double labeled: red - Muc1; green - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S4A Lats1/2^PanKO E12.0

S4A WT E12.5 ©

Specimen S4A WT E12.5: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Surface reconstruction of confocal Z stack images. Double labeled: red - Muc1; green - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present	Regionally restricted	S4A WT E12.5	Staining was localized to microlumens.

Specimen S4A Lats1/2^PanKO E12.5: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Surface reconstruction of confocal Z stack images. Double labeled: red - Muc1; green - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Weak		S4A Lats1/2^PanKO E12.5	A marked progressive loss of MUC1 protein was observed prior to the second transition.

S4E WT lower ©

S4E WT upper ©

Specimen S4E WT: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: red - Muc1; magenta - Lamc1 (assay MGI:8351675); green - Myl2 (assay MGI:8352275).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S4E WT lower , S4E WT upper

Specimen S4E Lats1/2^PanKO: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: red - Muc1; magenta - Lamc1 (assay MGI:8351675); green - Myl2 (assay MGI:8352275).

Structure	Level	Pattern	Image	Note
TS20: pancreas	Weak		S4E Lats1/2^PanKO upper , S4E Lats1/2^PanKO lower

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/06/2026 MGI 6.29