Wwtr1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8348239
Gene symbol:	Wwtr1
Gene name:	WW domain containing transcription regulator 1

Antibody:	anti-TAZ/WWTR1 (HPA007415)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

S1J WT lower ©

S1J WT upper ©

Specimen S1J WT: embryonic day 12.0 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Wwtr1; magenta - Cdh1 (assay MGI:8346384).

Structure	Cell Type	Level	Pattern	Image	Note
TS20: pancreas epithelium	epithelial cell of pancreas	Present	Regionally restricted	S1J WT upper , S1J WT lower	Nuclear expression was detected in a subset of wild type epithelial cells.

Specimen S1J Lats1/2^PanKO: embryonic day 12.0; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Wwtr1; magenta - Cdh1 (assay MGI:8346384).

Structure	Cell Type	Level	Pattern	Image	Note
TS20: pancreas epithelium	epithelial cell of pancreas	Present	Regionally restricted	S1J Lats1/2^PanKO upper , S1J Lats1/2^PanKO lower	Increased nuclear expression was detected in Lats1/2<PanKO> pancreas.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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