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Gene Expression Data
Assay Details
Assay
Reference: J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8351665
Gene symbol: Nfkb1
Gene name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Antibody: Anti-Phospho-NF-kappaB p105 (Ser932) (178F3) (4808)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 5A: embryonic day 12.0 (more )
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Nfkb1; magenta - Cdh1 (assay MGI:8346384).
Structure Level Pattern Image Note
TS20: pancreas epithelium Present Regionally restricted 5A A subset of cells was labeled in the wild type.
Specimen 5B: embryonic day 12.0; Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant. Double labeled: green - Nfkb1; magenta - Cdh1 (assay MGI:8346384).
Structure Level Pattern Image Note
TS20: pancreas epithelium Present Regionally restricted 5B A significantly higher proportion of cells were labelled in the Lats1/2<PanKO>, with almost double the number of immunopositive cells per section.
Specimen 5D: embryonic day 14.5 (more )
Note: Controls were either wild type or heterozygous littermates. Triple labeled: green - Nfkb1; magenta - Cdh1 (assay MGI:8346384); red - pHH3.
Structure Level Pattern Image Note
TS22: pancreas Present Regionally restricted 5D , 5D inset green Approximately 49% of immunopositive progenitor cells were pHH3+ in wild type.
Specimen 5E: embryonic day 14.5; Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more )
Note: Conditional mutant. Triple labeled: green - Nfkb1; magenta - Cdh1 (assay MGI:8346384); red - pHH3.
Structure Level Pattern Image Note
TS22: pancreas Present Regionally restricted 5E inset green , 5E Approximately 49% of immunopositive progenitor cells were pHH3+ in Lats1/2<PanKO>.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
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