Ptprc Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8352881
Gene symbol:	Ptprc
Gene name:	protein tyrosine phosphatase receptor type C

Antibody:	Anti-Ptprc (AF114)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

S8E WT lower ©

S8E WT upper ©

Specimen S8E WT E11.5: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Ptprc; magenta - Ctnnb1 (assay MGI:8351284).

Structure	Cell Type	Level	Pattern	Image	Note
TS19: pancreas primordium	leukocyte	Ambiguous		S8E WT upper , S8E WT lower

Specimen S8E Lats1/2^PanKO E11.5: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Ptprc; magenta - Ctnnb1 (assay MGI:8351284).

Structure	Cell Type	Level	Pattern	Image	Note
TS19: pancreas primordium	leukocyte	Present	Single cells	S8E Lats1/2^PanKO upper , S8E Lats1/2^PanKO lower	A few PTPRC+ leukocytes were located outside the Lats1/2<PanKO> pancreas bud epithelial periphery.

S8G WT lower ©

S8G WT upper ©

Specimen S8E WT E14.5: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Ptprc; magenta - Cdh1 (assay MGI:8346384).

Structure	Cell Type	Level	Pattern	Image	Note
TS22: pancreas epithelium	leukocyte	Ambiguous		S8G WT lower , S8G WT upper

Specimen S8E Lats1/2^PanKO E14.5: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Ptprc; magenta - Cdh1 (assay MGI:8346384).

Structure	Cell Type	Level	Pattern	Image	Note
TS22: pancreas epithelium	leukocyte	Present		S8G Lats1/2^PanKO upper , S8G Lats1/2^PanKO lower	By E14.5, leukocyte infiltrate could be detected within the epithelium and was significantly increased in Lats1/2<PanKO> pancreas relative to wild type.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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