Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: BALB/cJ * C57BL/6 * SJL
|
postnatal lethality, complete penetrance |
J:182515
|
Chuktm1Ver/Chuktm1Ver
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129/Sv * 129S4/SvJae * C57BL/6J
|
broad limb buds |
J:63443
|
|
curly tail |
J:63443
|
|
lethality throughout fetal growth and development, complete penetrance |
J:63443
|
|
open neural tube |
J:63443
|
Chuktm1Ver/Chuktm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129/Sv * 129S4/SvJae * C57BL/6J
|
broad limb buds |
J:63443
|
|
curly tail |
J:63443
|
Chuktm1Yhu/Chuktm1Yhu
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
|
epidermal hyperplasia |
J:141162
|
|
postnatal lethality |
J:141162
|
|
thick epidermis |
J:141162
|
Faslpr/Faslpr
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129/Sv * C57BL/6
|
liver inflammation |
J:92470
|
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6
|
decreased susceptibility to experimental autoimmune encephalomyelitis |
J:114741
|
|
normal
immune system phenotype |
J:114741
|
Fastm1Cgn/Fastm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6
|
decreased susceptibility to experimental autoimmune encephalomyelitis |
J:114741
|
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
|
abnormal lymph node cortex morphology |
J:119206
|
|
abnormal lymph node primary follicle morphology |
J:119206
|
|
abnormal lymph node secondary follicle morphology |
J:119206
|
|
absent lymph node germinal center |
J:119206
|
|
absent spleen germinal center |
J:119206
|
|
increased eosinophil cell number |
J:119206
|
|
increased leukocyte cell number |
J:119206
|
|
increased lymphocyte cell number |
J:119206
|
|
increased susceptibility to fungal infection |
J:119206
|
|
lung inflammation |
J:119206
|
|
small Peyer's patches |
J:119206
|
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
normal
integument phenotype |
J:208995
|
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * DBA/2
|
normal
integument phenotype |
J:208995
|
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(KRT14-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * DBA/2
|
epidermal hyperplasia |
J:208995
|
|
skin inflammation |
J:208995
|
|
skin lesions |
J:208995
|
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
|
postnatal lethality |
J:54323
|
Ikbkgtm1.1Dwat/Ikbkgtm1.1Dwat
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
|
premature death |
J:202106
|
Ikbkgtm1.1Dwat/Y
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
|
abnormal hepatocyte morphology |
J:202106
|
|
abnormal liver physiology |
J:202106
|
|
abnormal liver regeneration |
J:202106
|
|
hepatic steatosis |
J:202106
|
|
normal
immune system phenotype |
J:202106
|
|
increased circulating alanine transaminase level |
J:202106
|
|
increased circulating aspartate transaminase level |
J:202106
|
|
increased circulating bilirubin level |
J:202106
|
|
increased circulating lactate dehydrogenase level |
J:202106
|
|
liver fibrosis |
J:202106
|
|
liver inflammation |
J:202106
|
|
macrovesicular hepatic steatosis |
J:202106
|
|
microvesicular hepatic steatosis |
J:202106
|
|
premature death |
J:202106
|
|
preweaning lethality, incomplete penetrance |
J:202106
|
Il1r1tm1Imx/Il1r1tm1Imx
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S7/SvEvBrd * C57BL/6
|
abnormal chemokine level |
J:126652
|
|
decreased interleukin-6 secretion |
J:115094
|
|
decreased susceptibility to experimental autoimmune uveoretinitis |
J:115094
|
|
dental pulp necrosis |
J:58851
|
|
impaired neutrophil recruitment |
J:126652
|
|
increased bone resorption |
J:58851
|
|
increased susceptibility to bacterial infection |
J:58851
|
|
interstitial pneumonia |
J:126652
|
|
lung inflammation |
J:126652
|
|
osteomyelitis |
J:58851
|
Lepob/Lepob
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * C57BL/6
|
abnormal adipose tissue morphology |
J:55722
|
|
abnormal metabolism |
J:55722
|
|
decreased circulating insulin level |
J:55722
|
Map3k7tm1Aki/Map3k7tm1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6
|
normal
cardiovascular system phenotype |
J:191285
|
|
normal
cellular phenotype |
J:191285
|
|
dilated vasculature |
J:191285
|
|
embryonic lethality during organogenesis, complete penetrance |
J:191285
|
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2
|
normal
immune system phenotype |
J:312394
|
|
normal
integument phenotype |
J:312394
|
Rag1tm1Bal/Rag1tm1Bal
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129/Sv * C57BL/6
|
liver inflammation |
J:92470
|
Relatm1.1Gho/Relatm1.1Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
|
abnormal eye development |
J:134684
|
|
blindness |
J:134684
|
|
premature death |
J:134684
|
|
prenatal lethality, incomplete penetrance |
J:134684
|
Relatm1.2Gho/Relatm1.2Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
|
premature death |
J:134684
|
Relatm1Bal/Relatm1Bal
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S4/SvJae * C57BL/6
|
abnormal spleen germinal center morphology |
J:60742
|
|
abnormal thymus morphology |
J:60742
|
|
decreased body size |
J:60742
|
|
decreased spleen white pulp amount |
J:60742
|
|
extramedullary hematopoiesis |
J:60742
|
|
focal hepatic necrosis |
J:60742
|
|
heart inflammation |
J:60742
|
|
liver inflammation |
J:60742
|
|
lung inflammation |
J:60742
|
|
postnatal lethality, complete penetrance |
J:60742
|
Relatm2.1Gho/Relatm2.1Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac
|
abnormal corneal epithelium morphology |
J:163663
|
|
corneal vascularization |
J:163663
|
|
decreased cornea thickness |
J:163663
|
|
increased corneal epithelium thickness |
J:163663
|
|
increased incidence of corneal inflammation |
J:163663
|
|
liver fibrosis |
J:163663
|
|
liver inflammation |
J:163663
|
|
premature death |
J:163663
|
Ripk3tm2Vmd/Ripk3tm2Vmd
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: C57BL/6 * C57BL/6N
|
embryonic lethality prior to tooth bud stage |
J:209137
|
Tab2tm2.1Aki/Tab2tm2.1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6
|
abnormal vascular development |
J:191285
|
|
embryonic lethality during organogenesis, complete penetrance |
J:191285
|
Tbk1tm1Yeh/Tbk1tm1Yeh
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129P2/OlaHsd * C57BL/6J
|
normal
mortality/aging |
J:91653
|
Tg(CAG-Lyn*)#Paau/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * DBA/2
|
normal
integument phenotype |
J:151886
|
Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+
involves: 129P2/OlaHsd * C57BL/6 * CBA
|
abnormal nervous system physiology |
J:106592
|
|
demyelination |
J:106592
|
Tg(INS-Il10)#Sar/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6J * NOD
|
increased circulating glucose level |
J:64051
|
|
increased susceptibility to autoimmune diabetes |
J:64051
|
Tg(KRT5-Nfkbia*)3Rto/0
Tg(Krt5-Tnfr1)#Rsab/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * CBA
|
epidermal hyperplasia |
J:208995
|
|
postnatal lethality, incomplete penetrance |
J:208995
|
|
skin inflammation |
J:208995
|
Tg(TNF)197Gkl/0
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129 * C57BL/6 * CBA
|
arthritis |
J:92470
|
TnfBpsm1/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6
|
increased circulating tumor necrosis factor level |
J:226052
|
|
normal
skeleton phenotype |
J:226052
|
TnfBpsm1/TnfBpsm1
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6
|
increased circulating tumor necrosis factor level |
J:226052
|
|
normal
skeleton phenotype |
J:226052
|
Tnfem5Boui/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1a+
involves: 129S2/SvPas * C57BL/6
|
abnormal lung morphology |
J:306876
|
|
arthritis |
J:306876
|
|
cardiovalvulitis |
J:306876
|
|
colitis |
J:306876
|
|
premature death |
J:306876
|
|
preweaning lethality, incomplete penetrance |
J:306876
|
Tnftm1Gkl/Tnftm1Gkl
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129S/SvEv * C57BL/6
|
normal
immune system phenotype |
J:92470
|
Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
|
normal
cardiovascular system phenotype |
J:264147
|
Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/?
involves: 129S/SvEv * C57BL/6 * CBA
|
arthritis |
J:131930
|
|
small intestinal inflammation |
J:131930
|
Tnftm2Gkl/Tnftm2Gkl
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
|
increased circulating tumor necrosis factor level |
J:54056
|
|
increased tumor necrosis factor secretion |
J:54056
|
Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Vil1-cre)997Gum/0
involves: 129S2/SvPas * C57BL/6 * SJL
|
decreased susceptibility to induced colitis |
J:163410
|
|
increased susceptibility to induced colitis |
J:163410
|
Tnfaip3tm1Ama/Tnfaip3tm1Ama
Tnfrsf1atm1Imx/Tnfrsf1a+
involves: C57BL/6J
|
abnormal inflammatory response |
J:92694
|
|
cachexia |
J:92694
|
|
decreased body size |
J:92694
|
|
premature death |
J:92694
|
Tnfaip3tm1Ama/Tnfaip3tm1Ama
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: C57BL/6J
|
abnormal inflammatory response |
J:92694
|
|
cachexia |
J:92694
|
|
decreased body size |
J:92694
|
|
premature death |
J:92694
|
Tnfaip8l1em1Huwa/Tnfaip8l1em1Huwa
Tnfrsf1aem2Smoc/Tnfrsf1aem2Smoc
Tnfrsf1bem1Smoc/Tnfrsf1bem1Smoc
C57BL/6-Tnfrsf1bem1Smoc Tnfrsf1aem2Smoc Tnfaip8l1em1Huwa
|
normal
digestive/alimentary phenotype |
J:342074
|
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129/Sv * C57BL/6
|
liver inflammation |
J:92470
|
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
|
abnormal lymph node cortex morphology |
J:119206
|
|
abnormal lymph node primary follicle morphology |
J:119206
|
|
abnormal lymph node secondary follicle morphology |
J:119206
|
|
absent lymph node germinal center |
J:119206
|
|
absent spleen germinal center |
J:119206
|
|
decreased IgG1 level |
J:115225
|
|
decreased susceptibility to experimental autoimmune encephalomyelitis |
J:115225
|
|
normal
immune system phenotype |
J:119206
|
|
increased susceptibility to parasitic infection |
J:114203
|
|
small Peyer's patches |
J:119206
|
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Il1r1tm1Imx/Il1r1tm1Imx
B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J
|
abnormal brain wave pattern |
J:137505
|
|
abnormal circadian temperature homeostasis |
J:137505
|
|
abnormal sleep pattern |
J:137505
|
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Ins2-Cxcl13)1Cys/0
involves: C57BL/6 * DBA/2
|
abnormal lymph organ development |
J:110548
|
|
abnormal pancreatic islet morphology |
J:110548
|
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Thy1-APP)3Somm/0
involves: C57BL/6 * C57BL/6J * DBA/2
|
amyloid beta deposits |
J:134832
|
|
normal
behavior/neurological phenotype |
J:134832
|
|
cerebral amyloid angiopathy |
J:134832
|
|
microgliosis |
J:134832
|
|
normal
nervous system phenotype |
J:134832
|
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
B6.129S-Tnfrsf1btm1Imx Tnfrsf1atm1Imx/J
|
decreased susceptibility to Coronaviridae infection |
J:288523
|
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * C57BL/6
|
abnormal body temperature homeostasis |
J:48865
|
|
abnormal bone healing |
J:70467
|
|
abnormal glial cell physiology |
J:78637
|
|
abnormal kidney morphology |
J:69294
|
|
abnormal nervous system morphology |
J:78637
|
|
abnormal neuron physiology |
J:33864
|
|
abnormal retina blood vessel morphology |
J:104652
|
|
abnormal thrombosis |
J:117987
|
|
abnormal trabecular bone morphology |
J:70467
|
|
decreased food intake |
J:48865
|
|
decreased inflammatory response |
J:45147
|
|
decreased microglial cell activation |
J:33864
|
|
decreased physiological sensitivity to xenobiotic |
J:51349
|
|
decreased susceptibility to dopaminergic neuron neurotoxicity |
J:78637
|
|
decreased susceptibility to endotoxin shock |
J:45147
|
|
decreased susceptibility to experimental autoimmune uveoretinitis |
J:115094
|
|
decreased susceptibility to induced arthritis |
J:120707
|
|
decreased susceptibility to induced morbidity/mortality |
J:48865
|
|
dental pulp necrosis |
J:58851
|
|
impaired skeletal muscle regeneration |
J:104990
|
|
increased bone resorption |
J:58851
|
|
increased cerebral infarct size |
J:33864
|
|
increased circulating tumor necrosis factor level |
J:45147
|
|
increased myocardial infarct size |
J:62223
|
|
increased susceptibility to bacterial infection |
J:58851
|
|
increased susceptibility to neuronal excitotoxicity |
J:33864
|
|
normal
nervous system phenotype |
J:33864
|
|
osteomyelitis |
J:58851
|
|
pulmonary fibrosis |
J:51349
|
|
renal interstitial fibrosis |
J:69294
|
|
seizures |
J:112713
|
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Vasntm1Zgl/Vasntm1Zgl
involves: C57BL/6
|
normal
reproductive system phenotype |
J:173568
|
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
|
anemia |
J:180054
|
|
decreased body weight |
J:180054
|
|
decreased hemoglobin content |
J:180054
|
|
glomerulonephritis |
J:180054
|
|
increased neutrophil cell number |
J:180054
|
|
increased susceptibility to systemic lupus erythematosus |
J:180054
|
|
premature death |
J:180054
|
|
prenatal lethality, incomplete penetrance |
J:180054
|
|
spleen hyperplasia |
J:180054
|
Xbp1tm2Glm/Xbp1tm2Glm
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
|
small intestinal inflammation |
J:206084
|
Excel File
Analysis Tools