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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884
131 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: BALB/cJ * C57BL/6 * SJL
postnatal lethality, complete penetrance J:182515
Chuktm1Ver/Chuktm1Ver
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129/Sv * 129S4/SvJae * C57BL/6J
broad limb buds J:63443
curly tail J:63443
lethality throughout fetal growth and development, complete penetrance J:63443
open neural tube J:63443
Chuktm1Ver/Chuktm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129/Sv * 129S4/SvJae * C57BL/6J
broad limb buds J:63443
curly tail J:63443
Chuktm1Yhu/Chuktm1Yhu
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
epidermal hyperplasia J:141162
postnatal lethality J:141162
thick epidermis J:141162
Faslpr/Faslpr
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129/Sv * C57BL/6
liver inflammation J:92470
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6
decreased susceptibility to experimental autoimmune encephalomyelitis J:114741
normal immune system phenotype J:114741
Fastm1Cgn/Fastm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6
decreased susceptibility to experimental autoimmune encephalomyelitis J:114741
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
abnormal lymph node cortex morphology J:119206
abnormal lymph node primary follicle morphology J:119206
abnormal lymph node secondary follicle morphology J:119206
absent lymph node germinal center J:119206
absent spleen germinal center J:119206
increased eosinophil cell number J:119206
increased leukocyte cell number J:119206
increased lymphocyte cell number J:119206
increased susceptibility to fungal infection J:119206
lung inflammation J:119206
small Peyer's patches J:119206
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
normal integument phenotype J:208995
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * DBA/2
normal integument phenotype J:208995
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(KRT14-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * DBA/2
epidermal hyperplasia J:208995
skin inflammation J:208995
skin lesions J:208995
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
postnatal lethality J:54323
Ikbkgtm1.1Dwat/Ikbkgtm1.1Dwat
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
premature death J:202106
Ikbkgtm1.1Dwat/Y
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
abnormal hepatocyte morphology J:202106
abnormal liver physiology J:202106
abnormal liver regeneration J:202106
hepatic steatosis J:202106
normal immune system phenotype J:202106
increased circulating alanine transaminase level J:202106
increased circulating aspartate transaminase level J:202106
increased circulating bilirubin level J:202106
increased circulating lactate dehydrogenase level J:202106
liver fibrosis J:202106
liver inflammation J:202106
macrovesicular hepatic steatosis J:202106
microvesicular hepatic steatosis J:202106
premature death J:202106
preweaning lethality, incomplete penetrance J:202106
Il1r1tm1Imx/Il1r1tm1Imx
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S7/SvEvBrd * C57BL/6
abnormal chemokine level J:126652
decreased interleukin-6 secretion J:115094
decreased susceptibility to experimental autoimmune uveoretinitis J:115094
dental pulp necrosis J:58851
impaired neutrophil recruitment J:126652
increased bone resorption J:58851
increased susceptibility to bacterial infection J:58851
interstitial pneumonia J:126652
lung inflammation J:126652
osteomyelitis J:58851
Lepob/Lepob
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * C57BL/6
abnormal adipose tissue morphology J:55722
abnormal metabolism J:55722
decreased circulating insulin level J:55722
Map3k7tm1Aki/Map3k7tm1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6
normal cardiovascular system phenotype J:191285
normal cellular phenotype J:191285
dilated vasculature J:191285
embryonic lethality during organogenesis, complete penetrance J:191285
Rag1tm1Bal/Rag1tm1Bal
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129/Sv * C57BL/6
liver inflammation J:92470
Relatm1.1Gho/Relatm1.1Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
abnormal eye development J:134684
blindness J:134684
premature death J:134684
prenatal lethality, incomplete penetrance J:134684
Relatm1.2Gho/Relatm1.2Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
premature death J:134684
Relatm1Bal/Relatm1Bal
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S4/SvJae * C57BL/6
abnormal spleen germinal center morphology J:60742
abnormal thymus morphology J:60742
decreased body size J:60742
decreased spleen white pulp amount J:60742
extramedullary hematopoiesis J:60742
focal hepatic necrosis J:60742
heart inflammation J:60742
liver inflammation J:60742
lung inflammation J:60742
postnatal lethality, complete penetrance J:60742
Relatm2.1Gho/Relatm2.1Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac
abnormal corneal epithelium morphology J:163663
corneal vascularization J:163663
decreased cornea thickness J:163663
increased corneal epithelium thickness J:163663
increased incidence of corneal inflammation J:163663
liver fibrosis J:163663
liver inflammation J:163663
premature death J:163663
Ripk3tm2Vmd/Ripk3tm2Vmd
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: C57BL/6 * C57BL/6N
embryonic lethality prior to tooth bud stage J:209137
Tab2tm2.1Aki/Tab2tm2.1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6
abnormal vascular development J:191285
embryonic lethality during organogenesis, complete penetrance J:191285
Tbk1tm1Yeh/Tbk1tm1Yeh
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129P2/OlaHsd * C57BL/6J
normal mortality/aging J:91653
Tg(CAG-Lyn*)#Paau/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * DBA/2
normal integument phenotype J:151886
Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal nervous system physiology J:106592
demyelination J:106592
Tg(INS-Il10)#Sar/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6J * NOD
increased circulating glucose level J:64051
increased susceptibility to autoimmune diabetes J:64051
Tg(KRT5-Nfkbia*)3Rto/0
Tg(Krt5-Tnfr1)#Rsab/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * CBA
epidermal hyperplasia J:208995
postnatal lethality, incomplete penetrance J:208995
skin inflammation J:208995
Tg(TNF)197Gkl/0
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129 * C57BL/6 * CBA
arthritis J:92470
TnfBpsm1/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6
increased circulating tumor necrosis factor level J:226052
normal skeleton phenotype J:226052
TnfBpsm1/TnfBpsm1
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6
increased circulating tumor necrosis factor level J:226052
normal skeleton phenotype J:226052
Tnftm1Gkl/Tnftm1Gkl
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129S/SvEv * C57BL/6
normal immune system phenotype J:92470
Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
normal cardiovascular system phenotype J:264147
Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/?
involves: 129S/SvEv * C57BL/6 * CBA
arthritis J:131930
small intestinal inflammation J:131930
Tnftm2Gkl/Tnftm2Gkl
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
increased circulating tumor necrosis factor level J:54056
increased tumor necrosis factor secretion J:54056
Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Vil1-cre)997Gum/0
involves: 129S2/SvPas * C57BL/6 * SJL
decreased susceptibility to induced colitis J:163410
increased susceptibility to induced colitis J:163410
Tnfaip3tm1Ama/Tnfaip3tm1Ama
Tnfrsf1atm1Imx/Tnfrsf1a+
involves: C57BL/6J
abnormal inflammatory response J:92694
cachexia J:92694
decreased body size J:92694
premature death J:92694
Tnfaip3tm1Ama/Tnfaip3tm1Ama
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: C57BL/6J
abnormal inflammatory response J:92694
cachexia J:92694
decreased body size J:92694
premature death J:92694
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129/Sv * C57BL/6
liver inflammation J:92470
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
abnormal lymph node cortex morphology J:119206
abnormal lymph node primary follicle morphology J:119206
abnormal lymph node secondary follicle morphology J:119206
absent lymph node germinal center J:119206
absent spleen germinal center J:119206
decreased IgG1 level J:115225
decreased susceptibility to experimental autoimmune encephalomyelitis J:115225
normal immune system phenotype J:119206
increased susceptibility to parasitic infection J:114203
small Peyer's patches J:119206
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Il1r1tm1Imx/Il1r1tm1Imx
B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J
abnormal brain wave pattern J:137505
abnormal circadian temperature homeostasis J:137505
abnormal sleep pattern J:137505
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Ins2-Cxcl13)1Cys/0
involves: C57BL/6 * DBA/2
abnormal lymph organ development J:110548
abnormal pancreatic islet morphology J:110548
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Thy1-APP)3Somm/0
involves: C57BL/6 * C57BL/6J * DBA/2
amyloid beta deposits J:134832
normal behavior/neurological phenotype J:134832
cerebral amyloid angiopathy J:134832
microgliosis J:134832
normal nervous system phenotype J:134832
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
B6.129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
decreased susceptibility to Coronaviridae infection J:288523
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * C57BL/6
abnormal body temperature homeostasis J:48865
abnormal bone healing J:70467
abnormal glial cell physiology J:78637
abnormal kidney morphology J:69294
abnormal nervous system morphology J:78637
abnormal neuron physiology J:33864
abnormal retinal blood vessel morphology J:104652
abnormal thrombosis J:117987
abnormal trabecular bone morphology J:70467
decreased food intake J:48865
decreased inflammatory response J:45147
decreased microglial cell activation J:33864
decreased physiological sensitivity to xenobiotic J:51349
decreased sensitivity to induced morbidity/mortality J:48865
decreased susceptibility to dopaminergic neuron neurotoxicity J:78637
decreased susceptibility to endotoxin shock J:45147
decreased susceptibility to experimental autoimmune uveoretinitis J:115094
decreased susceptibility to induced arthritis J:120707
dental pulp necrosis J:58851
impaired skeletal muscle regeneration J:104990
increased bone resorption J:58851
increased cerebral infarction size J:33864
increased circulating tumor necrosis factor level J:45147
increased myocardial infarction size J:62223
increased susceptibility to bacterial infection J:58851
increased susceptibility to neuronal excitotoxicity J:33864
normal nervous system phenotype J:33864
osteomyelitis J:58851
pulmonary fibrosis J:51349
renal interstitial fibrosis J:69294
seizures J:112713
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Vasntm1Zgl/Vasntm1Zgl
involves: C57BL/6
normal reproductive system phenotype J:173568
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
anemia J:180054
decreased body weight J:180054
decreased hemoglobin content J:180054
glomerulonephritis J:180054
increased neutrophil cell number J:180054
increased susceptibility to systemic lupus erythematosus J:180054
premature death J:180054
prenatal lethality, incomplete penetrance J:180054
spleen hyperplasia J:180054
Xbp1tm2Glm/Xbp1tm2Glm
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
small intestinal inflammation J:206084

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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory