Chuk^tm1Yhu
Targeted Allele Detail

Summary

• Symbol: Chuk^tm1Yhu
• Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Yinling Hu
• MGI ID: MGI:3817541
• Synonyms: Ikkalpha^F
• Gene: Chuk Location: Chr19:44061774-44095919 bp, - strand Genetic Position: Chr19, 36.71 cM
• Alliance: Chuk^tm1Yhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141162
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of exon 5 and an additional loxP site was inserted downstream of exon 8. Transient cre expression in ES cells was used to remove the neo cassette leaving exons 6 through 8 floxed. (J:141162)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chuk Mutation: 48 strains or lines available

References

• Original: J:141162 Liu B, et al., IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell. 2008 Sep 9;14(3):212-25
• All: 16 reference(s)