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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chuktm1Yhu
targeted mutation 1, Yinling Hu
MGI:3817541
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0 		B6.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj MGI:3817617
cn2
 		Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0 		FVB.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj MGI:3817618
cn3
 		Chuktm1Yhu/Chuktm1Yhu
Egfrtm1Mag/Egfrtm1Mag
Tg(KRT5-cre)5132Jlj/0 		involves: 129 * C57BL/6 * CD-1 MGI:3817622
cn4
 		Chuktm1Yhu/Chuktm1Yhu
Egfrtm1Mag/Egfr+
Tg(KRT5-cre)5132Jlj/0 		involves: 129 * C57BL/6 * CD-1 MGI:3817623
cn5
 		Chuktm1Yhu/Chuktm1Yhu
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT5-cre)5132Jlj/0 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3817624
cn6
 		Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3817613
cn7
 		Chuktm1Yhu/Chuktm1Yhu
Tg(KRT14-cre)1Cgn/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3817620
cn8
 		Chuktm1Yhu/Chuktm1Yhu
Egfrwa2/Egfrwa2
Tg(KRT5-cre)5132Jlj/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3817621
cn9
 		Chuktm1Yhu/Chuktm1Yhu
Tg(MMTV-cre)4Mam/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB MGI:3817625
cn10
 		Chuktm1Yhu/Chuktm1Yhu
Tg(Krt1-15-cre/PGR*)22Cot/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3817626
cn11
 		Chuktm1Yhu/Chuktm1Yhu
Tg(Krt1-5-cre/ERT)1Ipc/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3817627


Genotype
MGI:3817617
cn1
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 B6.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:141162 )
• Background Sensitivity: compared to on a congenic FVB background, mice exhibit later lethality

integument
thick skin ( J:141162 )
• Background Sensitivity: compared to on a congenic FVB background, mice exhibit less skin thickening




Genotype
MGI:3817618
cn2
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 FVB.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:141162 )
• Background Sensitivity: compared to on a congenic C57BL/6 background, mice exhibit earlier lethality

integument
thick skin ( J:141162 )
• Background Sensitivity: compared to on a congenic C57BL/6 background, mice exhibit more skin thickening




Genotype
MGI:3817622
cn3
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Egfrtm1Mag/Egfrtm1Mag
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129 * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Egfrtm1Mag mutation (1 available); any Egfr mutation (85 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:141162 )
• mice die 3 days after birth




Genotype
MGI:3817623
cn4
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Egfrtm1Mag/Egfr+
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129 * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Egfrtm1Mag mutation (1 available); any Egfr mutation (85 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:141162 )
• most mice die but some survive
premature death ( J:141162 )
• most mice die but some survive

vision/eye
abnormal eye morphology ( J:141162 )
• mice exhibit eye defects

integument
abnormal coat/ hair morphology ( J:141162 )
• mice exhibit hair defects
thick epidermis ( J:141162 )
• slightly




Genotype
MGI:3817624
cn5
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:141162 )
• mice die slightly earlier than Chuktm1Yhu/Chuktm1Yhu Tg(KRT5-cre)1Jlj mice

integument
epidermal hyperplasia ( J:141162 )
• as in Chuktm1Yhu/Chuktm1Yhu Tg(KRT5-cre)1Jlj mice
thick epidermis ( J:141162 )
• as in Chuktm1Yhu/Chuktm1Yhu Tg(KRT5-cre)1Jlj mice




Genotype
MGI:3817613
cn6
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:141162 )
• most mice die between 12 and 16 days after birth and all are dead by day 22

digestive/alimentary system
small esophagus ( J:141162 )
• the esophagus is small

growth/size/body
postnatal growth retardation ( J:141162 )

skeleton
abnormal skeleton morphology ( J:141162 )
• at birth, mice resemble Chuktm1Mka homozygotes

integument
increased keratinocyte proliferation ( J:141162 )
• mice exhibit increased keratinocyte cell numbers compared to in wild-type mice
abnormal skin morphology ( J:141162 )
• at birth, mice resemble Chuktm1Mka homozygotes
abnormal keratinocyte differentiation ( J:141162 )
• hyperproliferative keratinocytes do not terminally differentiate
epidermal hyperplasia ( J:141162 )
• mice exhibit epidermal hyperproliferation that is keratinocyte autonomous
thick epidermis ( J:141162 )
• beginning at P5 and gradually increasing through lifespan
• however, treatment with GW2974, an EGFR and ErbB2 inhibitor, can reduce epidermal thickening
wrinkled skin ( J:141162 )
• 5 days after birth
thick skin ( J:141162 )
• 5 days after birth

cellular
abnormal keratinocyte differentiation ( J:141162 )
• hyperproliferative keratinocytes do not terminally differentiate
increased keratinocyte proliferation ( J:141162 )
• mice exhibit increased keratinocyte cell numbers compared to in wild-type mice




Genotype
MGI:3817620
cn7
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal skin morphology ( J:141162 )
• at birth, some mice resemble Chuktm1Mpa homozygotes
epidermal hyperplasia ( J:141162 )
• some mice exhibit epidermal hyperplasia after birth




Genotype
MGI:3817621
cn8
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Egfrwa2/Egfrwa2
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Egfrwa2 mutation (3 available); any Egfr mutation (85 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

integument
integument phenotype ( J:141162 )
N
• mice exhibit normal epidermal thickness
abnormal epidermal layer morphology ( J:141162 )
• epidermal proliferation is less than in Chuktm1Yhu/Chuktm1Yhu Tg(KRT5-cre)1Jlj mice




Genotype
MGI:3817625
cn9
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tg(MMTV-cre)4Mam/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(MMTV-cre)4Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:141162 )
• at 1 to 5 months of age, mice begin to develop skin tumors on their faces

integument
sparse hair ( J:141162 )
• 3 weeks after birth
epidermal hyperplasia ( J:141162 )
• in the dorsal epidermis
increased skin tumor incidence ( J:141162 )
• at 1 to 5 months of age, mice begin to develop skin tumors on their faces




Genotype
MGI:3817626
cn10
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tg(Krt1-15-cre/PGR*)22Cot/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:141162 )
• all mice develop skin tumors four months after RU846 induction
increased skin papilloma incidence ( J:141162 )
• after RU846 induction
increased carcinoma incidence ( J:141162 )
• after RU846 induction

integument
increased skin tumor incidence ( J:141162 )
• all mice develop skin tumors four months after RU846 induction
increased skin papilloma incidence ( J:141162 )
• after RU846 induction




Genotype
MGI:3817627
cn11
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:141162 )
• 10 to 12 months following induction with tamoxifen

integument
epidermal hyperplasia ( J:141162 )
• after tamoxifen induction, mice exhibit dorsal epidermis hyperplasia
increased skin tumor incidence ( J:141162 )
• 10 to 12 months following induction with tamoxifen




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory