Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chuktm1Mpa
Name:	conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Manolis Pasparakis
MGI ID:	MGI:3714160
Synonyms:	Ikk1FL
Gene:	Chuk  Location: Chr19:44061774-44095919 bp, - strand  Genetic Position: Chr19, 36.71 cM
Alliance:	Chuktm1Mpa page

Germline Transmission:	Earliest citation of germline transmission: J:122320
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion     Lox P sites were inserted 3' of exon 5 and 5' of exon 9. (J:122320)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chuk Mutation:	48 strains or lines available

Original:	J:122320 Gareus R, et al., Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol. 2007 Apr;9(4):461-9
All:	13 reference(s)