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Ptpn11
Gene Detail
 Symbol
Name
ID
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511
Synonyms 2700084A17Rik, PTP1D, PTP2C, SH2 domain-containing protein tyrosine phosphatase-2, Shp2, SHP-2, SH-PTP2, Syp
Feature Type protein coding gene
Genetic Map
Chromosome 5
61.72 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:121130533-121191397 bp, - strand
From VEGA annotation of GRCm38

  60865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2122  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 6/11 types
Gene Tree: Ptpn11

Human
homologs
Human Homolog PTPN11, protein tyrosine phosphatase, non-receptor type 11
NCBI Gene ID 5781
neXtProt AC  NX_Q06124
Human Synonyms  BPTP3, CFC, NS1, PTP-1D, PTP2C, SHP2, SH-PTP2, SH-PTP3
Human Chr (Location)  12q24; chr12:112418732-112509918 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human PTPN11
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(16) Targeted(20)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit abnormal mesoderm patterning leading to a failure of gastrulation and death by embryonic day 10.5. In heterozygous state the null mutant acts as a dominant enhancer of a mild epidermal growth factor receptor mutation.
 
Human Diseases Modeled Using Mouse Ptpn11 (3)    Alleles Annotated to Human Diseases(3)    Phenotype Images(3)
Interactions
Ptpn11 interacts with 308 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process abortive mitotic cell cycle, activation of MAPK activity, ...
Component cell junction, cytoplasm, ...
Function D1 dopamine receptor binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (103)    Tissues (78)    Images (9)
Theiler Stages: 10, 18, 19, 20, 21, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 29
Northern blot 4
Western blot 13
RT-PCR 53
cDNA source data(208)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(212) Genomic(1) cDNA(209) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016267 (Evidence)
Ensembl Gene ModelENSMUSG00000043733 (Evidence)
Entrez Gene19247 (Evidence)
UniGene8681
DFCITC1576000, TC1579898, TC1586142, TC1647511
DoTSDT.535201, DT.97335308, DT.97398512
NIA Mouse Gene IndexU026679
EC3.1.3.48
PDB1AYA, 1AYB, 1AYC, 1AYD
Consensus CDS ProjectCCDS39247.1, CCDS51637.1
International Mouse Knockout Project StatusPtpn11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016267 VEGA Gene Model | MGI Sequence Detail 60865 C57BL/6J ±  kb
transcript OTTMUST00000039010 VEGA | MGI Sequence Detail 5599 Not Applicable 
polypeptide OTTMUSP00000017430 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro IPR000980 SH2 domain
Protein Ontology PR:000013449 tyrosine-protein phosphatase non-receptor type 11
References (Earliest) J:19469 Feng GS, et al., SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science. 1993 Mar 12;259(5101):1607-11
(Latest) J:210890 Goodwin CB, et al., PI3K p110delta uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML. Blood. 2014 May 1;123(18):2838-42
All references(192)
Disease annotation references (6)
Other
accession IDs
MGD-MRK-16288, MGI:1919896, MGI:2141206

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory