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Ptpn11
Gene Detail
Symbol

Name
ID
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511
Synonyms
2700084A17Rik, PTP1D, PTP2C, SH2 domain-containing protein tyrosine phosphatase-2, Shp2, SHP-2, SH-PTP2, Syp
Feature Type
protein coding gene
Genetic Map
Chromosome 5
61.72 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:121130533-121191397 bp, - strand
From VEGA annotation of GRCm38

  60865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2122  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PTPN11
Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 6/11 types
Gene Tree: Ptpn11

Human
homologs
PTPN11, protein tyrosine phosphatase, non-receptor type 11
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5781
neXtProt AC: NX_Q06124

Human Synonyms: BPTP3, CFC, NS1, PTP-1D, PTP2C, SHP2, SH-PTP2, SH-PTP3

Human Chr (Location): 12q24; chr12:112418732-112509918 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human PTPN11

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(16) Targeted(21) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants exhibit abnormal mesoderm patterning leading to a failure of gastrulation and death by embryonic day 10.5. In heterozygous state the null mutant acts as a dominant enhancer of a mild epidermal growth factor receptor mutation.
 
Human Diseases Modeled in Mice Using Ptpn11 (3)    Mutations Annotated to Human Diseases (6)    Phenotype Images(3)
Interactions
Ptpn11 interacts with 308 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (91 annotations)
Process abortive mitotic cell cycle, activation of MAPK activity, ...
Component cell junction, cytoplasm, ...
Function D1 dopamine receptor binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (102)    Tissues (77)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 29
Northern blot 4
Western blot 12
RT-PCR 53
cDNA source data(208)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase MGC107851 ; ZFIN ptpn11a    NEW 
Molecular
reagents
All nucleic(212) Genomic(1) cDNA(209) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016267 (Evidence)
Ensembl Gene Model ENSMUSG00000043733 (Evidence)
Entrez Gene 19247 (Evidence)
UniGene 8681
DFCI TC1576000, TC1579898, TC1586142, TC1647511
DoTS DT.535201, DT.97335308, DT.97398512
NIA Mouse Gene Index U026679
EC 3.1.3.48
PDB 1AYA, 1AYB, 1AYC, 1AYD
Consensus CDS Project CCDS39247.1, CCDS51637.1
International Mouse Phenotyping Consortium Status Ptpn11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016267 VEGA Gene Model | MGI Sequence Detail 60865 C57BL/6J ±  kb
transcript OTTMUST00000039010 VEGA | MGI Sequence Detail 5599 Not Applicable 
polypeptide OTTMUSP00000017430 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro IPR000980 SH2 domain
Protein Ontology PR:000013449 tyrosine-protein phosphatase non-receptor type 11
References
(Earliest) J:19469 Feng GS, et al., SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science. 1993 Mar 12;259(5101):1607-11
(Latest) J:220894 Zhou Y, et al., SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion. FASEB J. 2015 May;29(5):1635-45
All references(198)
Disease annotation references (10)
Other
accession IDs
MGD-MRK-16288, MGI:1919896, MGI:2141206

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory