Ptpn11
Gene Detail

Symbol Name ID

Ptpn11 protein tyrosine phosphatase, non-receptor type 11 MGI:99511

Synonyms

2700084A17Rik, PTP1D, PTP2C, SH2 domain-containing protein tyrosine phosphatase-2, Shp2, SHP-2, SH-PTP2, Syp

Feature Type

protein coding gene

Genetic Map

Chromosome 5

61.72 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:121130533-121191397 bp, - strand From VEGA annotation of GRCm38   60865 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2122  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 6/11 types
Gene Tree: Ptpn11

Human homologs

Human Homolog		PTPN11, protein tyrosine phosphatase, non-receptor type 11
NCBI Gene ID		5781
neXtProt AC		NX_Q06124
Human Synonyms		BPTP3, CFC, NS1, PTP-1D, PTP2C, SHP2, SH-PTP2, SH-PTP3
Human Chr (Location)		12q24; chr12:112856536-112947717 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human PTPN11

Alleles and phenotypes

All alleles(36) : Targeted(20) Gene trapped(16)
 

Homozygous null mutants exhibit abnormal mesoderm patterning leading to a failure of gastrulation and death by embryonic day 10.5. In heterozygous state the null mutant acts as a dominant enhancer of a mild epidermal growth factor receptor mutation.

 
Human Diseases Modeled Using Mouse Ptpn11 (3)    Alleles Annotated to Human Diseases(3)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (66 annotations)

Process	activation of MAPK activity, atrioventricular canal development, ...
Component	cell junction, cytoplasm, ...
Function	hydrolase activity, insulin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (103)    Tissues (76)    Images (9)
Theiler Stages: 10, 18, 19, 20, 21, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	29
Northern blot	4
Western blot	13
RT-PCR	53

cDNA source data(205)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(209) Genomic(1) cDNA(206) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016267 (Evidence)
Ensembl Gene Model	ENSMUSG00000043733 (Evidence)
Entrez Gene	19247 (Evidence)
UniGene	8681
DFCI	TC1576000, TC1579898, TC1586142, TC1647511
DoTS	DT.535201, DT.97335308, DT.97398512
NIA Mouse Gene Index	U026679
EC	3.1.3.48
PDB	1AYA, 1AYB, 1AYC, 1AYD
Consensus CDS Project	CCDS39247.1, CCDS51637.1
International Mouse Knockout Project Status	Ptpn11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016267	VEGA Gene Model | MGI Sequence Detail	60865	C57BL/6J
transcript	OTTMUST00000039010	VEGA | MGI Sequence Detail	5599	Not Applicable
polypeptide	OTTMUSP00000017430	VEGA | MGI Sequence Detail	593	Not Applicable

All sequences(53) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000387	Protein-tyrosine/Dual-specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR012152	Protein-tyrosine phosphatase, non-receptor type-6, -11
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000013449	tyrosine-protein phosphatase non-receptor type 11

References

(Earliest) J:19469 Feng GS, et al., SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science. 1993 Mar 12;259(5101):1607-11
(Latest) J:193632 Nabinger SC, et al., The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo. Leukemia. 2013 Feb;27(2):398-408
All references(165)

Other accession IDs

MGD-MRK-16288, MGI:1919896, MGI:2141206