|
Symbol Name ID |
Ptpn11
protein tyrosine phosphatase, non-receptor type 11 MGI:99511 |
| Darker colors indicate more annotations |
| Human Phenotypes | Low posterior hairline |
Cystic hygroma |
Thickened nuchal skin fold |
Short neck |
Webbed neck |
Hepatomegaly |
Aplasia/Hypoplasia of the abdominal wall musculature |
Delayed puberty |
Delayed menarche |
Short stature |
Failure to thrive in infancy |
Postnatal growth retardation |
| Disease(s) Associated with PTPN11 | ||||||||||||
| Noonan syndrome | ||||||||||||
| Noonan syndrome 1 | ||||||||||||
| Noonan syndrome with multiple lentigines 1 |
| Mouse Phenotypes | heart left ventricle hypertrophy |
increased heart weight |
enlarged heart |
cardiac hypertrophy |
abnormal nasal bone morphology |
absent nasal capsule |
abnormal facial morphology |
abnormal tongue morphology |
depressed nasal bridge |
abnormal nasal cartilage morphology |
broad snout |
flattened snout |
small snout |
small ears |
embryonic growth retardation |
increased lean body mass |
decreased body weight |
slow postnatal weight gain |
weight loss |
obese |
abnormal chest morphology |
pectus carinatum |
pectus excavatum |
microcephaly |
decreased body length |
increased body length |
decreased susceptibility to diet-induced obesity |
increased susceptibility to weight gain |
decreased body size |
postnatal growth retardation |
decreased fetal size |
increased lung weight |
enlarged liver |
liver hyperplasia |
enlarged spleen |
increased spleen weight |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||
| Ptpn11tm1Paw/Ptpn11tm1Paw | |||||||||||||||||||||||||||||||||||||
| Ptpn11tm7Bgn/Ptpn11tm7Bgn | |||||||||||||||||||||||||||||||||||||
| Ptpn11tm1.1Ics/Ptpn11+ | |||||||||||||||||||||||||||||||||||||
| Ptpn11tm1Bgn/Ptpn11+ | |||||||||||||||||||||||||||||||||||||
| Ptpn11tm4.2Bgn/Ptpn11+ | |||||||||||||||||||||||||||||||||||||
| Ptpn11tm7Bgn/Ptpn11+ | |||||||||||||||||||||||||||||||||||||
| Tg(Myh7-Ptpn11*Q79R)11Rbns/0 | |||||||||||||||||||||||||||||||||||||
| Tg(Myh7-Ptpn11*Q510E)#Krnz/0 | |||||||||||||||||||||||||||||||||||||
| Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Camk2a-cre)2Szi/0 (conditional) |
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| Ptpn11tm1Gsf/Ptpn11tm1Gsf Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Ckmm-cre)5Khn/0 (conditional) |
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| Hprt1tm1(CAG-cre)Mnn/Hprt1+ Ptpn11tm1Ckq/Ptpn11+ (conditional) |
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| Ptpn11tm1Ckq/Ptpn11+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Ptpn11tm6Bgn/Ptpn11+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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