Phenotypes for Ptpn11 MGI:2176525 MGI Mouse

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:43740 )

• die around E10-11

growth/size/body

embryonic growth retardation ( J:43740 )

• E8.5 embryos are small and appear similar in size to wild-type E7.5 embryos

embryo

abnormal gastrulation ( J:43740 )

failure of initiation of embryo turning ( J:43740 )

• do not initiate the process of turning

abnormal rostral-caudal axis patterning ( J:43740 )

• about 30% fail to develop an A-P axis or any recognizable embryonic structures

• E8.5 embryos fail to elongate posteriorly

caudal body truncation ( J:43740 )

• some E9.5 embryos develop a defined A-P axis, however all exhibit varying degrees of posterior truncations

embryonic growth arrest ( J:43740 )

• 30% arrest development prior to the formation of recognizable structures

embryonic growth retardation ( J:43740 )

• E8.5 embryos are small and appear similar in size to wild-type E7.5 embryos

abnormal axial mesoderm morphology ( J:43740 )

• development of axial mesodermal structures is severely affected

abnormal neural tube morphology ( J:43740 )

• variable neural tube defects

abnormal embryonic neuroepithelium morphology ( J:43740 )

• disorganized neuroectoderm

open neural tube ( J:43740 )

• headfolds do not fuse at the midline at E9

kinked neural tube ( J:43740 )

• severely affected mutants have a kinked neural tube

abnormal notochord morphology ( J:43740 )

• E8.5 embryos do not develop a notochord

• abnormal notochord at E9.5; some have multiple, split, or kinked notochords

incomplete somite formation ( J:43740 )

• poorly developed somites, with some mutants able to form somites whereas others fail to make any recognizable somites

abnormal allantois morphology ( J:43740 )

• allantois does not develop properly and does not connect to the placenta

abnormal visceral yolk sac morphology ( J:43740 )

• yolk sac is abnormally thin and wrinkled

abnormal vitelline vascular remodeling ( J:43740 )

• yolk sac blood vessels fail to re-organize into a highly vascularized network at E9.5 and remain in a honeycombed pattern seen in E8.5 wild-type embryos, however vasculogenesis and production of the capillary plexus occurs normally

• thick-walled blood vessels do not form in yolk sacs

cardiovascular system

abnormal heart development ( J:43740 )

• heart forms abnormally

nervous system