Ptpn11tm1Paw
Targeted Allele Detail
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Symbol: |
Ptpn11tm1Paw |
Name: |
protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Anthony Pawson |
MGI ID: |
MGI:2176524 |
Synonyms: |
Shp-2 -, Shp2 -, Shp-2delta46-110 |
Gene: |
Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
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Alliance: |
Ptpn11tm1Paw page
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Defects in the skin, lung and intestine of Egfrwa2/Egfrwa2 Ptpn11tm1Paw/+ mice
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 3, which contains sequences encoding the SH2-N motif. RT-PCR analysis on total RNA derived from heterozygous mice demonstrated that a transcript was made from this allele that spliced exon 2 to exon 4, resulting in a message that retained the proper reading frame. Western blot analysis on heterozygous specimins confirmed that a mutant protein is expressed from this allele that is consistent with the size expected.
(J:43740)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ptpn11 Mutation: |
43 strains or lines available
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Original: |
J:43740 Saxton TM, et al., Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 1997 May 1;16(9):2352-64 |
All: |
14 reference(s) |
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