|
Symbol Name ID |
Ptpn11
protein tyrosine phosphatase, non-receptor type 11 MGI:99511 |
| Darker colors indicate more annotations |
| Human Phenotypes | Lymphedema |
Chylothorax |
Increased level of L-fucose in urine |
| Disease(s) Associated with PTPN11 | |||
| Noonan syndrome | |||
| Noonan syndrome 1 | |||
| stomach cancer |
| Mouse Phenotypes | increased cardiac muscle triglyceride level |
pericardial effusion |
decreased susceptibility to diet-induced obesity |
decreased circulating glucose level |
hypoglycemia |
hyperglycemia |
abnormal circulating hormone level |
increased circulating corticosterone level |
decreased circulating insulin level |
increased circulating insulin level |
decreased circulating leptin level |
increased circulating leptin level |
increased circulating growth hormone level |
increased circulating thyroid-stimulating hormone level |
decreased circulating thyroxine level |
decreased circulating triiodothyronine level |
decreased circulating triglyceride level |
increased circulating triglyceride level |
increased circulating interleukin-6 level |
decreased circulating alanine transaminase level |
increased circulating alanine transaminase level |
increased circulating aspartate transaminase level |
abnormal atrial thrombosis |
decreased body temperature |
increased energy expenditure |
hydrops fetalis |
abnormal glucose homeostasis |
impaired glucose tolerance |
improved glucose tolerance |
increased liver glycogen level |
increased insulin sensitivity |
insulin resistance |
decreased circulating adiponectin level |
abnormal lipid level |
increased glycerol level |
decreased liver triglyceride level |
increased liver triglyceride level |
decreased skeletal muscle triglyceride level |
increased skeletal muscle triglyceride level |
abnormal carbohydrate metabolism |
enhanced lipolysis |
increased incidence of tumors by chemical induction |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||
| Ptpn11tm1Bgn/Ptpn11tm1Bgn | |||||||||||||||||||||||||||||||||||||||||||
| Ptpn11tm1.1Ics/Ptpn11+ | |||||||||||||||||||||||||||||||||||||||||||
| Tg(Myh7-Ptpn11*Q79R)11Rbns/0 | |||||||||||||||||||||||||||||||||||||||||||
| Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Camk2a-cre)2Szi/0 (conditional) |
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| Ptpn11tm1Gsf/Ptpn11tm1Gsf Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Ckmm-cre)5Khn/0 (conditional) |
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| Ptpn11tm3Bgn/Ptpn11tm3Bgn Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Ptpn11tm3Bgn/Ptpn11tm3Bgn (conditional) | |||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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