Ptpn11^tm1Rbn
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm1Rbn
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Daniel U Rabin
• MGI ID: MGI:2176526
• Synonyms: syp
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm1Rbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35137
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 2 and flanking sequences. Western blot analysis on lyastes prepared from various tissues of heterozygous mice confirmed that protein levels were reduced by 40-50% in all tissue examined. (J:35137)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 43 strains or lines available

Notes

ES cell line = G1 (Bayer Corp., unpublished). This appears to have been derived from an unspecified subline of 129.

References

• Original: J:35137 Arrandale JM, et al., Insulin signaling in mice expressing reduced levels of Syp. J Biol Chem. 1996 Aug 30;271(35):21353-8
• All: 2 reference(s)