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Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

Phenotype annotations related to neoplasm

Darker colors indicate more annotations

Human Phenotypes	Juvenile myelomonocytic leukemia	Stomach cancer	Multiple enchondromatosis	Exostoses	Multiple exostoses	Multiple digital exostoses	Neurofibrosarcoma
Disease(s) Associated with PTPN11	Juvenile myelomonocytic leukemia	Stomach cancer	Multiple enchondromatosis	Exostoses	Multiple exostoses	Multiple digital exostoses	Neurofibrosarcoma
juvenile myelomonocytic leukemia
metachondromatosis
Noonan syndrome
Noonan syndrome 1
stomach cancer

Mouse Phenotypes		increased lymphoblastic lymphoma incidence	increased incidence of tumors by chemical induction	increased liver adenoma incidence	increased leukemia incidence	increased acute lymphoblastic leukemia incidence	increased acute promyelocytic leukemia incidence	increased B cell derived lymphoma incidence
Availability	Mouse Genotype	increased lymphoblastic lymphoma incidence	increased incidence of tumors by chemical induction	increased liver adenoma incidence	increased leukemia incidence	increased acute lymphoblastic leukemia incidence	increased acute promyelocytic leukemia incidence	increased B cell derived lymphoma incidence
	Ptpn11^tm1Gsf/Ptpn11^tm1Gsf Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)
	Cd19^tm1(cre)Cgn/Cd19⁺ Ptpn11^tm1Ckq/Ptpn11⁺ (conditional)
	Ptpn11^tm1Ckq/Ptpn11⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)
	Ptpn11^tm1Ckq/Ptpn11⁺ Tg(Mx1-cre)1Cgn/0 (conditional)
	Ptpn11^tm1Ckq/Ptpn11⁺ Tg(Lck-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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