Phenotype Images associated with this Transgene

Nomenclature

Symbol:	Speer6-ps1^{Tg(Alb-cre)21Mgn}
Name:	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
MGI ID:	MGI:2176228
Synonyms:	Alb^cre, Alb-cre, AlbCre, Alb-Cre, Alb^cre2, albumin-cre, cr^Alb, Cre^ALB, Tg(Alb-cre)21Mg

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Analysis of livers in mice with heterozygous and homozygous Fbxw7^tm1.1Iken mutations
	Liver histology in mice with heterozygous and homozygous Fbxw7^tm1.1Iken mutations in combination with an oncogenic KrasG12D mutation
	RNA oxidation in Glul^tm1.1Geno/Glul^tm1.1Geno Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mouse brain	Glul^tm1.1Geno/Glul^tm1.1Geno Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * C57BL/6J * DBA
	The leucine metabolite 2-ketoisocaproate induces liver steatosis in Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	B6.Cg-Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}
	Abnormalities of mitochondrial ultrastructure in Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 hepatocytes	Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	B6.Cg-Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}
	Hepatomegaly and tumor-like protrusions in the liver of Ei24^tm1Hzha/Ei24^tm1Hzha Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Ei24^tm1Hzha/Ei24^tm1Hzha Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
	Enlarged spleen and swollen liver mitochondria in Ei24^tm1Hzha/Ei24^tm1Hzha Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Ei24^tm1Hzha/Ei24^tm1Hzha Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
	Kinked spermatozoa in Selenop^tm3.1Rfb/Selenop^tm3.1Rfb Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice fed a selenium-deficient diet	Selenop^tm3.1Rfb/Selenop^tm3.1Rfb Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA
	Curling and splaying of hind limbs in Selenop^tm3.1Rfb/Selenop^tm3.1Rfb Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice fed a selenium-deficient diet	Selenop^tm3.1Rfb/Selenop^tm3.1Rfb Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA
	Abnormal liver structure in Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
	Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice develop hepatitis and fibrosis with age	Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
	Mir122^tm1.1Kgh/Mir122^tm1.1Kgh and Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice develop hepatocellular carcinoma	Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
		Mir122^tm1.1Kgh/Mir122^tm1.1Kgh	involves: 129S1/Sv * 129X1/SvJ
		Mir122^tm1.2Kgh/Mir122^tm1.2Kgh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA
		Mir122^tm1.1Kgh/Mir122^tm1.1Kgh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
		Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA
	Atherosclerosis lesion area is increased in Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice and TO901317 treatment reduces these lesions	Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
	Increase in macrophage content in Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 aortic root	Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
	Hepatomegaly in Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * C57BL/6N * DBA
	Liver steatosis in Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * C57BL/6N * DBA
	Hepatocyte abnormalities in Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * C57BL/6N * DBA
	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 livers contain multiple large empty vacuoles	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * C57BL/6N * DBA
	Livers of Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice conatin fewer hepatocytes	Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * C57BL/6 * DBA * SJL
	Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice do not develop liver tumors in response to activated Ras	Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * C57BL/6 * DBA * SJL
	Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 hepatocytes do not enter mitosis after partial hepatectomy	Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * C57BL/6 * DBA * SJL
	Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice are resistant to dioxin-induced hepatic damage	Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Aip^tm2.1Bra
	Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice are resistant to dioxin-induced hepatic damage	Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Aip^tm2.1Bra
	Decreased glycogen liver content in Gys2^tm1.1Pro/Gys2^tm1.1Pro Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Gys2^tm1.1Pro/Gys2^tm1.1Pro Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
	Pcyt2^tm1.1Suja/Pcyt2^tm1.1Suja Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 liver with hepatocytes engorged with lipid droplets	Pcyt2^tm1.1Suja/Pcyt2^tm1.1Suja Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA
	Decreased bone density in Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S4/SvJaeSor * C57BL/6 * DBA
	Pale liver in Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S4/SvJaeSor * C57BL/6 * DBA
	Hepatic steatosis in Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S4/SvJaeSor * C57BL/6 * DBA
	Increased apoptosis in liver of Adar^tm1Knk/Adar^tm1Knk Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Adar^tm1Knk/Adar^tm1Knk Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
	Vascular tumors in Vhl^tm1.1Jae/Vhl⁺ livers and vascular lesions in Vhl^tm1Jae/Vhl^tm1Jae Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice	Vhl^tm1.1Jae/Vhl⁺	involves: 129S4/SvJae * BALB/c
		Vhl^tm1Jae/Vhl^tm1Jae Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

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