Ghr^tm1.1Masp
Targeted Allele Detail

Summary

• Symbol: Ghr^tm1.1Masp
• Name: growth hormone receptor; targeted mutation 1.1, Mark A Sperling
• MGI ID: MGI:4359891
• Synonyms: Ghr^fl
• Gene: Ghr Location: Chr15:3347237-3612834 bp, - strand Genetic Position: Chr15, 1.84 cM
• Alliance: Ghr^tm1.1Masp page

Decreased bone density in Ghr^tm1.1Masp/Ghr^tm1.1Masp Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 4 and an frt flanked neo cassette with a 5' loxP site. Germ line, flp mediated recombination removed the neo cassette leaving exon 4. (J:152627)

Generation of the Ghr^tm1.1Masp and Ghr^tm1.2Masp alleles

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghr Mutation: 49 strains or lines available

References

• Original: J:152627 Fan Y, et al., Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem. 2009 Jul 24;284(30):19937-44
• All: 6 reference(s)