Gys2tm1.1Pro
Targeted Allele Detail
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Symbol: |
Gys2tm1.1Pro |
Name: |
glycogen synthase 2; targeted mutation 1.1, Peter J Roach |
MGI ID: |
MGI:4462836 |
Synonyms: |
Gys2(Lox) |
Gene: |
Gys2 Location: Chr6:142368339-142418835 bp, - strand Genetic Position: Chr6, 74.04 cM
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Alliance: |
Gys2tm1.1Pro page
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Decreased glycogen liver content in Gys2tm1.1Pro/Gys2tm1.1Pro Speer6-ps1Tg(Alb-cre)21Mgn/0 mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:162043
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 5, and a floxed neo cassette was inserted downstream of exon 6. Cre mediated recombination removes the neo cassette leaving exons 5 and 6 floxed.
(J:162043)
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Generation of the floxed Gys2tm1.1Pro allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gys2 Mutation: |
45 strains or lines available
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Original: |
J:162043 Irimia JM, et al., Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. J Biol Chem. 2010 Apr 23;285(17):12851-61 |
All: |
2 reference(s) |
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