Phenotypes associated with this allele

• Allele Symbol: Gys2^tm1.1Pro
• Allele Name: targeted mutation 1.1, Peter J Roach
• Allele ID: MGI:4462836
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gys2^tm1.1Pro/Gys2^tm1.1Pro Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA	MGI:4462847

Genotype
MGI:4462847

cn1

• Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased glycogen liver content in Gys2^tm1.1Pro/Gys2^tm1.1Pro Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice

homeostasis/metabolism

impaired exercise endurance ( J:162043 )

• fed mice exhibit reduced exercise capacity compared with control Gys2^tm1.1Pro homozygotes

abnormal circulating ketone body level ( J:162043 )

• during a fast, mice exhibit a more acute increase in ketone bodies than in similarly treated control Gys2^tm1.1Pro homozygotes

abnormal glucose homeostasis ( J:162043 )

decreased circulating glucose level ( J:162043 )

• in fed and fasted states, mice exhibit reduced circulating glucose levels compared with similarly treated control Gys2^tm1.1Pro homozygotes

• mice enter a fasted state quicker than similarly treated control Gys2^tm1.1Pro homozygotes

decreased circulating insulin level ( J:162043 )

• under fed condition

abnormal gluconeogenesis ( J:162043 )

• mice exhibit enhanced gluconeogenesis compared with control Gys2^tm1.1Pro homozygotes

impaired glucose tolerance ( J:162043 )

decreased glycogen catabolism rate ( J:162043 )

decreased glycogen level ( J:162043 )

• glycogen liver content is reduced 94% compared to in control Gys2^tm1.1Pro homozygotes

• exercised mice exhibit a greater decrease in muscle glycogen levels compared with control Gys2^tm1.1Pro homozygotes

• however, glycogen content in the skeletal muscle and kidney is normal

abnormal triglyceride level ( J:162043 )

• fasting mice fail to exhibit a change in triglyceride levels unlike fasted control Gys2^tm1.1Pro homozygotes

increased liver triglyceride level ( J:162043 )

• at 7 and 15 months

cardiovascular system

decreased heart weight ( J:162043 )

decreased cardiac muscle cell glucose uptake ( J:162043 )

• heart glucose uptake is lower than in control Gys2^tm1.1Pro homozygotes

decreased systemic arterial diastolic blood pressure ( J:162043 )

liver/biliary system

increased liver triglyceride level ( J:162043 )

• at 7 and 15 months

decreased liver weight ( J:162043 )

muscle

decreased cardiac muscle cell glucose uptake ( J:162043 )

• heart glucose uptake is lower than in control Gys2^tm1.1Pro homozygotes

behavior/neurological

impaired exercise endurance ( J:162043 )

• fed mice exhibit reduced exercise capacity compared with control Gys2^tm1.1Pro homozygotes

cellular

decreased cardiac muscle cell glucose uptake ( J:162043 )

• heart glucose uptake is lower than in control Gys2^tm1.1Pro homozygotes