Phenotype Image Detail

Image

Caption

Macrophage staining. Aortic root sections from Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm (Ldlr^-/-/floxed) and Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (Ldlr^-/-/LivKO) mice fed a Western diet with or without 0.01% T0901317 for 20 weeks were stained with antibodies to MOMA-2 to detect macrophages (A, B). Date are mean +/- SEM. a, statistically significant difference between vehicle and T0901317 treated animals of the same genotype (p < 0.05). b, statistically significant difference between floxed and LivKO mice with the same treatment (p < 0.05).

Copyright

This image is from Zhang Y, J Clin Invest 2012 May 1;122(5):1688-99 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:184536

Associated Alleles

Symbol	Name
Ldlr^tm1Her	low density lipoprotein receptor; targeted mutation 1, Joachim Herz
Nr1h3^tm1.1Djm	nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, David J Mangelsdorf
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA