Pcyt2^tm1.1Suja
Targeted Allele Detail

Summary

• Symbol: Pcyt2^tm1.1Suja
• Name: phosphate cytidylyltransferase 2, ethanolamine; targeted mutation 1.1, Suzanne Jackowski
• MGI ID: MGI:4415290
• Synonyms: Pcyt2^fl
• Gene: Pcyt2 Location: Chr11:120500913-120508762 bp, - strand Genetic Position: Chr11, 84.33 cM, cytoband E2
• Alliance: Pcyt2^tm1.1Suja page

Pcyt2^tm1.1Suja/Pcyt2^tm1.1Suja Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 liver with hepatocytes engorged with lipid droplets

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155630
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:155630)

Generation of the Pcyt2^tm1.1Suja allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcyt2 Mutation: 25 strains or lines available

References

• Original: J:155630 Leonardi R, et al., Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis. J Biol Chem. 2009 Oct 2;284(40):27077-89
• All: 3 reference(s)