Phenotype Image Detail

Image

Caption

Abnormal liver structure in liver specific Mir122a knock-out (Mir122 LKO; Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/0) mice in early adult life. (C) Representative liver sections of 8-week-old control (floxed) and LKO mice after overnight fasting (n = 8-10 mice per genotype). Scale bars: top row, 200 um; bottom row, 25 um. (D) Oil red O- and PAS-stained liver sections from 8-week-old mutant mice after overnight fasting (n = 5 per genotype). Scale bars: top row, 100 um; bottom row, 100 um; insets, 25 um. (E) Transmission electron micrographs of liver sections from 12-week-old mutant mice. Lipid droplets (L), ER, mitochondria (M), and nucleus (N) are labeled. Scale bars: top row, 2 um; bottom row, 450 nm. (F) CK19 and A6 staining of bile duct and oval cells, respectively, in mutant livers (n = 3 mice per genotype). Scale bars: top row, 100 um; inset, 5 um; bottom row, 25 um.

Copyright

This image is from Hsu SH, J Clin Invest 2012 Aug 1;122(8):2871-83 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190067

Associated Alleles

Symbol	Name
Mir122^tm1.2Kgh	microRNA 122; targeted mutation 1.2, Kalpana Ghoshal
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA