Ei24^tm1Hzha
Targeted Allele Detail

Summary

• Symbol: Ei24^tm1Hzha
• Name: etoposide induced 2.4 mRNA; targeted mutation 1, Hong Zhang
• MGI ID: MGI:5475023
• Synonyms: Ei24^fl, Ei24^flox
• Gene: Ei24 Location: Chr9:36690449-36708630 bp, - strand Genetic Position: Chr9, 20.68 cM
• Alliance: Ei24^tm1Hzha page

Limb-clasping in Ei24^tm1Hzha/Ei24^tm1Hzha Tg(Nes-cre)1Kln/0 mice

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193420
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3. A neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:193420)

Scheme for generating the Ei24^tm1Hzha and Ei24^tm1.1Hzha alleles

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ei24 Mutation: 63 strains or lines available

References

• Original: J:193420 Zhao YG, et al., The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. J Biol Chem. 2012 Dec 7;287(50):42053-63
• All: 3 reference(s)