97 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Bcrtm1(BCR/ABL)Tsr/Bcr+ Runx1tm3Dow/Runx1+ Tg(Vav1-cre)#Cgp/0 involves: C57BL/6	decreased lymphocyte cell number	J:203111
	increased monocyte cell number	J:203111
	increased neutrophil cell number	J:203111
	premature death	J:203111
	thrombocytopenia	J:203111
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg Mapttm2Arbr/? Runx1tm1(cre/Esr1*)Ims/? involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	abnormal mechanoreceptor morphology	J:226826
Etv6tm1(RUNX1)Haho/Etv6+ Runx1tm3Spe/Runx1+ Tg(Mx1-cre)1Cgn/0 involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA	increased hematopoietic stem cell number	J:151639
Etv6tm1(RUNX1)Haho/Etv6+ Runx1tm3Spe/Runx1tm3Spe Tg(Mx1-cre)1Cgn/0 involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA	anemia	J:151639
	decreased hematopoietic stem cell number	J:151639
	premature death	J:151639
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Runx1tm2.1(cre/Esr1*)Ims/Runx1tm1Medv B6.Cg-Gt(ROSA)26Sortm1(EYFP)Cos Runx1tm2.1(cre/Esr1*)Ims	abnormal hematopoietic system morphology/development	J:182232
	normal hematopoietic system phenotype	J:182232
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru Runx1tm1Toku/Runx1tm1Toku Runx3tm1Itan/Runx3tm1Itan Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2	abnormal interferon secretion	J:131081
	increased CD4-positive, alpha-beta T cell number	J:131081
Hip1tm4Tsr/Hip1+ Runx1tm3Dow/Runx1+ Tg(Mx1-cre)1Cgn/0 involves: 129X1/SvJ * C57BL/6 * CBA	abnormal bone marrow cell morphology/development	J:151974
	abnormal bone marrow cell physiology	J:151974
	abnormal definitive hematopoiesis	J:151974
	abnormal liver morphology	J:151974
	abnormal liver parenchyma morphology	J:151974
	abnormal lung morphology	J:151974
	abnormal myelopoiesis	J:151974
	abnormal spleen B cell follicle morphology	J:151974
	abnormal spleen morphology	J:151974
	abnormal tumor morphology	J:151974
	decreased bone marrow cell number	J:151974
	decreased common myeloid progenitor cell number	J:151974
	decreased hematopoietic stem cell number	J:151974
	enlarged liver	J:151974
	enlarged spleen	J:151974
	extramedullary hematopoiesis	J:151974
	increased chronic myelocytic leukemia incidence	J:151974
	increased granulocyte number	J:151974
	increased hematopoietic stem cell number	J:151974
	increased leukocyte cell number	J:151974
	increased liver weight	J:151974
	increased neutrophil cell number	J:151974
	increased spleen red pulp amount	J:151974
	increased spleen weight	J:151974
	postnatal lethality	J:151974
	spleen hyperplasia	J:151974
Hprt1tm1(tetO-Runx1,-EGFP)Enk/Hprt1+ Sox10tm2(rtTA)Weg/Sox10+ involves: 129P2/OlaHsd	abnormal skin pigmentation	J:165939
	decreased birth body size	J:165939
	hyperresponsive to tactile stimuli	J:165939
	megacolon	J:165939
	postnatal lethality, complete penetrance	J:165939
	small dorsal root ganglion	J:165939
Mapttm2Arbr/? Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj	abnormal mechanoreceptor morphology	J:226826
Mapttm2Arbr/? Runx1tm3Spe/Runx1tm3Spe H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J	abnormal axon morphology	J:226826
	abnormal sensory neuron innervation pattern	J:226826
Runx1tm1(RUNX1/EVI1)Kmit/Runx1+ involves: C57BL/6 * CBA	abnormal embryonic hematopoiesis	J:118892
	abnormal megakaryocyte morphology	J:118892
	abnormal myelopoiesis	J:118892
	decreased erythrocyte cell number	J:118892
	embryonic lethality during organogenesis, complete penetrance	J:118892
	intraventricular hemorrhage	J:118892
Runx1tm1.1(RUNX1*)Homy/Runx1tm1.1(RUNX1*)Homy B6.129P2-Runx1tm1.1(RUNX1*)Homy	abnormal common myeloid progenitor cell morphology	J:164806
	abnormal megakaryocyte progenitor cell morphology	J:164806
	abnormal pericyte morphology	J:164806
	aneurysm	J:164806
	decreased erythroid progenitor cell number	J:164806
	decreased hematopoietic cell number	J:164806
	dilated vasculature	J:164806
	hemorrhage	J:164806
	impaired hematopoiesis	J:164806
	lethality throughout fetal growth and development, complete penetrance	J:164806
	pale liver	J:164806
	skin edema	J:164806
Runx1tm1.1Stkd/Runx1tm1.1Stkd Runx2tm1Mjo/Runx2tm1Mjo Tg(Col2a1-cre)1Star/0 involves: C57BL/6	abnormal skeleton morphology	J:158761
Runx1tm1.1Stkd/Runx1tm1.1Stkd Runx2tm1Mjo/Runx2tm1Mjo Tg(Prrx1-cre)1Cjt/0 involves: C57BL/6J * SJL/J	abnormal bone mineralization	J:158761
	abnormal chondrocyte differentiation	J:158761
	abnormal skeleton development	J:158761
	absent sternum	J:158761
	preweaning lethality, complete penetrance	J:158761
Runx1tm1Dez/Runx1+ involves: 129S4/SvJae * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:38705
	hemorrhage	J:38705
	impaired hematopoiesis	J:38705
Runx1tm1Soga/Runx1tm1Soga Stag2tm1.1Soga/Y Tg(Mx1-cre)1Cgn/0 involves: C57BL/6J * C57BL/6N * CBA/J	abnormal bone marrow cell physiology	J:289000
	abnormal myeloid cell morphology	J:289000
	anemia	J:289000
	decreased erythroid progenitor cell number	J:289000
	decreased leukocyte cell number	J:289000
	increased hematopoietic stem cell number	J:289000
	increased mean corpuscular volume	J:289000
	increased red blood cell distribution width	J:289000
Runx1tm1Tani/Runx1tm1Tani Runx3tm1Itan/Runx3tm1Itan Tg(Cd4-cre)1Cwi/? involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:125959
Runx1tm1Toku/Runx1+ Runx3tm1Itan/Runx3tm1Itan Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:131081
Runx1tm1Toku/Runx1tm1Toku involves: 129P2/OlaHsd * C57BL/6	abnormal T cell subpopulation ratio	J:87697
	increased CD4-positive, alpha-beta T cell number	J:87697
	small thymus	J:87697
	thymus hypoplasia	J:87697
Runx1tm1Toku/Runx1tm1Toku Runx3tm1Itan/Runx3+ Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:131081
	decreased CD8-positive, alpha-beta T cell number	J:131081
Runx1tm1Toku/Runx1tm1Toku Runx3tm1Itan/Runx3tm1Itan Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:131081
	decreased CD8-positive, alpha-beta T cell number	J:131081
Runx1tm1Toku/Runx1tm1Toku Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:131081
Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku involves: 129P2/OlaHsd * C57BL/6	abnormal T cell subpopulation ratio	J:87697
Runx1tm2.1(Runx1/Mecom)Homy/Runx1+ B6.129P2-Runx1tm2.1(Runx1/Mecom)Homy	no abnormal phenotype detected	J:164806
Runx1tm3(Runx3)Toku/Runx1tm3(Runx3)Toku involves: 129P2/OlaHsd	abnormal thymus medulla morphology	J:98965
	decreased body size	J:98965
	decreased body weight	J:98965
	decreased leukocyte cell number	J:98965
	decreased lymphocyte cell number	J:98965
	decreased thymocyte number	J:98965
	postnatal lethality, incomplete penetrance	J:98965
	small spleen	J:98965
	small thymus	J:98965
	thymus hypoplasia	J:98965
Runx1tm3Dow/Runx1+ Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal cell physiology	J:77129
	abnormal hematopoietic system morphology/development	J:77129
	decreased tumor-free survival time	J:77129
	normal hematopoietic system phenotype	J:77129
	increased acute promyelocytic leukemia incidence	J:77129
	increased sarcoma incidence	J:77129
	increased T cell derived lymphoma incidence	J:77129
	increased tumor incidence	J:77129
Runx1tm3Spe/Runx1tm3Spe Spi1tm2.1Dgt/Spi1tm2.1Dgt Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA	decreased B cell number	J:131217
	decreased thymus weight	J:131217
	increased granulocyte number	J:131217
	increased spleen weight	J:131217
Runx1tm3Spe/Runx1tm3Spe U2af1tm1.1Hev/U2af1+ Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * CBA/J	abnormal blood cell morphology	J:267082
	abnormal erythroid lineage cell morphology	J:267082
	abnormal myeloid cell morphology	J:267082
	increased incidence of tumors by chemical induction	J:267082
	increased myeloid cell number	J:267082
	increased susceptibility to induced morbidity/mortality	J:267082
	normal mortality/aging	J:267082
	thrombocytopenia	J:267082
Runx1tm4(Runx2)Toku/Runx1tm4(Runx2)Toku involves: 129P2/OlaHsd	decreased leukocyte cell number	J:98965
Runx1t1tm1Buch/Runx1t1+ Runx1tm1Buch/Runx1+ Tg(Nes-cre)1Atp/0 involves: FVB/N	no abnormal phenotype detected	J:68499