About   Help   FAQ
Targeted Allele Detail
Symbol: Runx2tm1Mjo
Name: runt related transcription factor 2; targeted mutation 1, Michael J Owen
MGI ID: MGI:2176465
Synonyms: Cbfa1-, Runx2-, Runx2LacZ
Gene: Runx2  Location: Chr17:44806873-45125518 bp, - strand  Genetic Position: Chr17, 21.33 cM
Alliance: Runx2tm1Mjo page
Trabecular bone and clavicle analysis in various mice with Runx2tm1Mjo and/or Hivep3tm1Glm alleles

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:40784
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsInsertion of an IRES-lacZ-neomycin resistance cassette into the exon encoding the Q/A repeat domain placed lacZ under the control of the endogenous promoter. (J:40784)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 334 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 31 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx2 Mutation:  42 strains or lines available
ES cell line = GK129 or R1.3
Original:  J:40784 Otto F, et al., Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997 May 30;89(5):765-71
All:  63 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.23
The Jackson Laboratory