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Runx2tm1Mjo
Targeted Allele Detail
Summary
Symbol: Runx2tm1Mjo
Name: runt related transcription factor 2; targeted mutation 1, Michael J Owen
MGI ID: MGI:2176465
Synonyms: Cbfa1-, Runx2-, Runx2LacZ
Gene: Runx2  Location: Chr17:44806873-45125518 bp, - strand  Genetic Position: Chr17, 21.33 cM
Alliance: Runx2tm1Mjo page
Trabecular bone and clavicle analysis in various mice with Runx2tm1Mjo and/or Hivep3tm1Glm alleles

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40784
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsInsertion of an IRES-lacZ-neomycin resistance cassette into the exon encoding the Q/A repeat domain placed lacZ under the control of the endogenous promoter. (J:40784)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 334 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 31 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx2 Mutation:  42 strains or lines available
Notes
ES cell line = GK129 or R1.3
References
Original:  J:40784 Otto F, et al., Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997 May 30;89(5):765-71
All:  63 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory