Phenotype Image Detail

Image

Caption

Genetic interaction analysis of Hivep3 (Shn3) with Runx2 in bone. (A, B) microCT analysis of the femurs from 10 week old wild-type (Shn3+/+), Runx2^tm1Mjo/Runx2⁺ (Runx2+/-), Hivep3^tm1Glm/Hivep3⁺ (Shn3+/-),Hivep3^tm1Glm/Hivep3⁺ Runx2^tm1Mjo/Runx2⁺ (Shn3+/-;Runx2+/-), Hivep3^tm1Glm/Hivep3^tm1Glm (Shn3-/-) and Hivep3^tm1Glm/Hivep3^tm1Glm Runx2^tm1Mjo/Runx2⁺ (Shn3-/-;Runx2+/-) mice. Displayed are three-dimensional reconstructions of trabecular bone (A), and values for bone volume fraction (BV/TV), trabecular number (Tb. N), and trabecular thickness (Tb. Th). Values are mean + SD (B). (C) Radiographs of 6 week old mice of the indicated genotypes were taken to demonstrate clavicular hypoplasia. Arrows indicate clavicles.

This image is from Shim JH, J Clin Invest 2013 Sep 3;123(9):4010-22 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201597

Associated
Alleles

Symbol	Name
Hivep3^tm1Glm	human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 1, Laurie H Glimcher
Runx2^tm1Mjo	runt related transcription factor 2; targeted mutation 1, Michael J Owen

Associated
Genotypes

Allelic Composition	Genetic Background
Runx2^tm1Mjo/Runx2⁺	Not Specified
Hivep3^tm1Glm/Hivep3⁺	involves: C57BL/6
Hivep3^tm1Glm/Hivep3^tm1Glm	involves: C57BL/6
Hivep3^tm1Glm/Hivep3^tm1Glm Runx2^tm1Mjo/Runx2⁺	involves: C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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