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Targeted Allele Detail
Symbol: Runx1tm1.1(RUNX1*)Homy
Name: runt related transcription factor 1; targeted mutation 1.1, Hiroaki Honda
MGI ID: MGI:4835663
Synonyms: Runx1deltaIRES
Gene: Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance: Runx1tm1.1(RUNX1*)Homy page
Germline Transmission:  Earliest citation of germline transmission: J:164806
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Humanized sequence, Hypomorph, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA cellular IRES in the 5' UTR of exon 3, the coding region of exon 3 and part of intron 3 were replaced with a floxed complete human RUNX1 splice variant B cDNA and an FRT flanked neo cassette via homologous recombination. The neo cassette was removed by flp mediated recombination. Blotting analysis indicated protein expression in whole homozygous embryos at E13.5 is similar to wild-type controls. (J:164806)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  35 strains or lines available
Original:  J:164806 Nagamachi A, et al., A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. Dev Biol. 2010 Sep 15;345(2):226-36
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory