185 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Bmp4tm1Blh/Bmp4+ Gli3Xt-J/Gli3+ involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd	abnormal autopod morphology	J:42445
	polydactyly	J:42445
Cdk20tm1.1Jegg/Cdk20tm1.1Jegg Gli3Xt-J/Gli3+ involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N	abnormal neural tube morphology	J:243907
Cdk20tm1.1Jegg/Cdk20tm1.1Jegg Gli3Xt-J/Gli3Xt-J involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N	normal embryo phenotype	J:243907
En1tm2(cre)Wrst/? Gli3tm1Alj/Gli3tm1Alj Smotm2Amc/Smotm2Amc involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal cerebellar foliation	J:137136
	abnormal cerebellum morphology	J:137136
	abnormal hindbrain morphology	J:137136
	abnormal rhombomere morphology	J:137136
	abnormal tectum morphology	J:137136
	enlarged cerebral aqueduct	J:137136
	enlarged tectum	J:137136
	normal nervous system phenotype	J:137136
	small cerebellum	J:137136
	thin external granule cell layer	J:137136
Fgf8tm1.4Mrt/Fgf8+ Gli3tm1.1Alj/Gli3tm1.1Alj involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	absent inferior colliculus	J:137136
	enlarged tectum	J:137136
	normal nervous system phenotype	J:137136
Gas1tm2Fan/Gas1tm2Fan Gli3Xt-J/Gli3Xt-J involves: 129/Sv * C3H/HeJ * C57BL/6J	polydactyly	J:121554
Gli1tm1Alj/Gli1tm1Alj Gli3Xt-J/Gli3+ involves: 129S1/Sv * 129X1/SvJ * CD-1	polydactyly	J:60986
Gli1tm2Alj/Gli1+ Gli2tm1Alj/Gli2tm1Alj Gli3Xt/Gli3Xt involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster	abnormal motor neuron morphology	J:87948
	abnormal neuron differentiation	J:87948
	abnormal neuronal precursor cell number	J:87948
	abnormal neuronal precursor proliferation	J:87948
	abnormal spinal cord morphology	J:87948
	abnormal ventral interneuron 3 morphology	J:87948
	abnormal ventral interneuron morphology	J:87948
	absent floor plate	J:87948
	decreased motor neuron number	J:87948
Gli2tm1Alj/Gli2+ Gli3Xt/Gli3Xt involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster	increased neuronal precursor cell number	J:87948
Gli2tm1Alj/Gli2+ Gli3Xt-J/Gli3+ involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1	polydactyly	J:38381
Gli2tm1Alj/Gli2+ Gli3Xt-J/Gli3Xt-J involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1	abnormal skeleton morphology	J:38381
	fusion of vertebral arches	J:38381
	polyphalangy	J:38381
Gli2tm1Alj/Gli2tm1Alj Gli3Xt-J/Gli3+ involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1	abnormal cartilage development	J:38381
	abnormal digit morphology	J:38381
	abnormal long bone morphology	J:38381
	abnormal skeleton morphology	J:38381
	abnormal vertebrae development	J:38381
	mandible hypoplasia	J:38381
	polydactyly	J:38381
	short femur	J:38381
	short fibula	J:38381
	short humerus	J:38381
	short radius	J:38381
	short tibia	J:38381
	short ulna	J:38381
	split sternum	J:38381
Gli2tm1Alj/Gli2tm1Alj Gli3Xt-J/Gli3Xt-J involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1	embryonic lethality, complete penetrance	J:38381
Gli2tm1Alj/Gli2tm1Alj Gli3Xt-J/Gli3Xt-J involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster	abnormal ventral interneuron 0 morphology	J:92067
	abnormal ventral interneuron 1 morphology	J:92067
	abnormal ventral interneuron 2 morphology	J:92067
	abnormal ventral interneuron 3 morphology	J:92067
	abnormal ventral interneuron morphology	J:92067
	decreased motor neuron number	J:92067
Gli2tm1Alj/Gli2tm1Alj Gli3Xt/Gli3+ involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster	increased neuronal precursor cell number	J:87948
Gli2tm1Alj/Gli2tm1Alj Gli3Xt/Gli3+ involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal lung bud morphology	J:49603
	abnormal lung development	J:49603
	abnormal lung morphology	J:49603
	abnormal tracheal cartilage morphology	J:49603
	esophageal atresia	J:49603
	pulmonary hypoplasia	J:49603
	trachea stenosis	J:49603
	tracheoesophageal fistula	J:49603
Gli2tm1Alj/Gli2tm1Alj Gli3Xt/Gli3Xt involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal endoderm development	J:49603
	abnormal esophagus development	J:49603
	abnormal foregut morphology	J:49603
	abnormal lung development	J:49603
	abnormal trachea development	J:49603
	absent esophagus	J:49603
	absent lungs	J:49603
	absent trachea	J:49603
	embryonic lethality during organogenesis, incomplete penetrance	J:49603
Gli2tm2.1Alj/Gli2+ Gli3Xt-J/Gli3Xt-J involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	abnormal mammary gland bud morphology	J:112460
Gli2tm2.1Alj/Gli2tm2.1Alj Gli3Xt-J/Gli3+ involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	normal reproductive system phenotype	J:112460
Gli2tm2.1Alj/Gli2tm2.1Alj Gli3Xt-J/Gli3Xt-J involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	embryonic lethality during organogenesis, complete penetrance	J:112460
Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj Gli3Xt-J/Gli3+ involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	abnormal mammary gland bud morphology	J:112460
Gli2tm3.1(Gli1)Alj/Gli2+ Gli3Xt-J/Gli3+ either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)	male infertility	J:73074
	polydactyly	J:73074
	premature death	J:73074
	progressive hair loss	J:73074
Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj Gli3Xt/Gli3Xt involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster	abnormal ventral interneuron 3 morphology	J:87948
	absent floor plate	J:87948
	normal limbs/digits/tail phenotype	J:87948
Gli3add/Gli3Xt involves: 101/H * C3H/HeH * C57BL/6 * CBA/H * SJL	abnormal digit development	J:11318
	polydactyly	J:11318
Gli3Mos1/Gli3+ Sox10tm1Weg/Sox10+ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	belly spot	J:136642
	belted	J:136642
	hypopigmentation	J:136642
Gli3TgBR/Gli3+ ScribCrc/ScribCrc involves: C57BL/6J * NMRI	abnormal innervation	J:77245
Gli3TgBR/Gli3Xt involves: 101/H * C3H/HeH * C57BL/6J * CBA/H	abnormal skeleton morphology	J:77245
	polydactyly	J:77245
Gli3tm1.1Alj/Gli3Xt involves: 101/H * 129S6/SvEvTac * C3H/HeH * C57BL/6 * CBA/H	abnormal cerebellar Purkinje cell layer	J:137136
	abnormal cerebellum morphology	J:137136
	abnormal hindbrain morphology	J:137136
	abnormal inferior colliculus morphology	J:137136
	abnormal midbrain morphology	J:137136
	abnormal rhombomere morphology	J:137136
	abnormal superior colliculus morphology	J:137136
	enlarged cerebral aqueduct	J:137136
	enlarged tectum	J:137136
	reduced cerebellar foliation	J:137136
Gli3tm1.2Zllr/Gli3+ Pkdcctm1.2Azun/Pkdcctm1.2Azun involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal scapula morphology	J:199462
	decreased length of long bones	J:199462
	delayed endochondral bone ossification	J:199462
	short humerus	J:199462
	short tibia	J:199462
Gli3tm1.2Zllr/Gli3tm1.2Zllr Pkdcctm1.2Azun/Pkdcctm1.2Azun involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cartilage development	J:199462
	abnormal scapula morphology	J:199462
	absent fibula	J:199462
	absent tibia	J:199462
	delayed endochondral bone ossification	J:199462
	polydactyly	J:199462
Gli3tm1Alj/Gli3+ Tgif1tm1Caw/Tgif1tm1Caw Tgif2tm1Dwot/Tgif2tm1Dwot Edil3Tg(Sox2-cre)1Amc/Edil3+ involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA	abnormal cephalic neural fold morphology	J:183402
	abnormal forebrain development	J:183402
	abnormal olfactory epithelium morphology	J:183402
	decreased embryonic neuroepithelial cell proliferation	J:183402
	exencephaly	J:183402
Gli3tm1Alj/Gli3tm1Alj Nkx3-2tm1(cre)Wez/Nkx3-2+ Smotm2Amc/Smotm2Amc involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ	abnormal digestive system morphology	J:199664
Gli3tm1Urt/Gli3tm1Urt Sufutm1.1Blnw/Sufutm1.1Blnw involves: 129 * C57BL/6 * CD-1 * FVB/N	normal nervous system phenotype	J:161408
Gli3tm2Blnw/Gli3+ Shhtm1Chg/Shhtm1Chg involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal autopod morphology	J:121609
	abnormal digit morphology	J:121609
	abnormal limb morphology	J:121609
	abnormal phalanx morphology	J:121609
	absent tibia	J:121609
	polydactyly	J:121609
	short tibia	J:121609
	synostosis	J:121609
Gli3Xt-J/Gli3+ Sox10tm1Weg/Sox10+ involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ	belly spot	J:136642
	belted	J:136642
	hypopigmentation	J:136642
Gli3Xt-J/Gli3+ Tulp3hhkr/Tulp3+ involves: C3H/HeH * C3H/HeJ * C57BL/6	polydactyly	J:147584
Gli3Xt-J/Gli3+ Tulp3hhkr/Tulp3hhkr involves: C3H/HeH * C3H/HeJ * C57BL/6	polydactyly	J:147584
Gli3Xt-J/Gli3+ Rr26tm1Svok/Rr26+ involves: 129X1/SvJ * C3H/HeJ	polydactyly	J:207959
Gli3Xt-J/Gli3+ Rr26tm1Svok/Rr26tm1Svok involves: 129X1/SvJ * C3H/HeJ	polydactyly	J:207959
Gli3Xt-J/Gli3+ Spoptm1c(KOMP)Mbp/Spoptm1c(KOMP)Mbp Tg(Prrx1-cre)1Cjt/0 involves: C3H/HeJ * C57BL/6J * C57BL/6N * SJL/J	normal skeleton phenotype	J:239074
Gli3Xt-J/Gli3Xt-J Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+ Ihhtm1Amc/Ihhtm1Amc Tg(Col2a1-cre)3Amc/0 involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ	abnormal long bone diaphysis morphology	J:154905
	decreased body size	J:154905
	perinatal lethality, complete penetrance	J:154905
	short limbs	J:154905
	normal skeleton phenotype	J:154905
Gli3Xt-J/Gli3Xt-J Hand2tm1.1Zllr/Hand2tm1.2Zllr Tg(Prrx1-cre)1Cjt/0 involves: 129 * BALB/cJ * C3H/HeJ * C57BL/6 * SJL	abnormal autopod morphology	J:159210
	abnormal forelimb stylopod morphology	J:159210
	abnormal forelimb zeugopod morphology	J:159210
	abnormal limb development	J:159210
	postaxial polydactyly	J:159210
	preaxial polydactyly	J:159210
Gli3Xt-J/Gli3Xt-J Ihhtm1Amc/Ihhtm1Amc involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ	abnormal bone marrow cavity morphology	J:154905
	abnormal perichondrium morphology	J:154905
Gli3Xt-J/Gli3Xt-J Skitm1Cco/Ski+ involves: C3H * C57BL/6	abnormal skeleton development	J:80205
	polydactyly	J:80205
Gli3Xt-J/Gli3Xt-J Tbx15de-H/Tbx15+ involves: C3H * C57BL/6J	abnormal scapula morphology	J:101708
	scapular bone foramen	J:101708
Gli3Xt-J/Gli3Xt-J Tbx15de-H/Tbx15de-H involves: C3H * C57BL/6J	small acromion	J:101708
	small scapula	J:101708
Gli3Xt-J/Gli3Xt-J Tmem107schlei/Tmem107schlei involves: C3H/HeJ * C3HeB/FeJ * C57BL/6J	abnormal floor plate morphology	J:186552
Gli3Xt-J/Gli3Xt-J Tulp3hhkr/Tulp3+ involves: C3H/HeH * C3H/HeJ * C57BL/6	polysyndactyly	J:147584
Gli3Xt-J/Gli3Xt-J Tulp3hhkr/Tulp3hhkr involves: C3H/HeH * C3H/HeJ * C57BL/6	lethality throughout fetal growth and development, complete penetrance	J:147584
Gli3Xt/Gli3+ involves: 101/H * 129 * C3H/HeH * C57BL/6	abnormal digit morphology	J:121609
	abnormal phalanx morphology	J:121609
	absent tibia	J:121609
	polydactyly	J:121609
Gli3Xt/Gli3Xt involves: 101/H * 129 * C3H/HeH * C57BL/6 * CBA/H	abnormal digit morphology	J:121609
	polydactyly	J:121609
Gli3Xt/Gli3Xt involves: 101/H * C3H/HeH * C57BL/6 * CBA/H	abnormal cerebellar Purkinje cell layer	J:137136
	abnormal cerebellum morphology	J:137136
	abnormal cerebral hemisphere morphology	J:19818
	abnormal choroid plexus morphology	J:19818
	abnormal folding of telencephalic vesicles	J:19818
	abnormal forebrain morphology	J:19818
	abnormal hindbrain morphology	J:137136
	abnormal inferior colliculus morphology	J:137136
	abnormal lateral ventricle morphology	J:19818
	abnormal midbrain morphology	J:137136
	abnormal rhombomere morphology	J:137136
	abnormal superior colliculus morphology	J:137136
	abnormal telencephalon development	J:19818
	absent olfactory bulb	J:19818
	delayed neural tube closure	J:19818
	enlarged cerebral aqueduct	J:137136
	enlarged tectum	J:137136
	incomplete rostral neuropore closure	J:19818
	normal nervous system phenotype	J:19818
	reduced cerebellar foliation	J:137136
Gli3Xt/Gli3Xt involves: 101/H * C3H/HeH * CBA/H	abnormal anterior cardinal vein morphology	J:5049
	abnormal axial skeleton morphology	J:5049
	abnormal brain morphology	J:5049
	abnormal cerebellum morphology	J:5049
	abnormal cerebral hemisphere morphology	J:5049
	abnormal cranial ganglia morphology	J:5049
	abnormal cranium morphology	J:5049
	abnormal ear development	J:5049
	abnormal epidermal layer morphology	J:5049
	abnormal eye development	J:5049
	abnormal forebrain morphology	J:5049
	abnormal forehead morphology	J:5049
	abnormal hindbrain morphology	J:5049
	abnormal hindlimb morphology	J:5049
	abnormal interfrontal bone morphology	J:5049
	abnormal kidney morphology	J:5049
	abnormal limb bone morphology	J:5049
	abnormal limb bud morphology	J:5049
	abnormal long bone morphology	J:5049
	abnormal maxilla morphology	J:5049
	abnormal medulla oblongata morphology	J:5049
	abnormal metacarpal bone morphology	J:5049
	abnormal metatarsal bone morphology	J:5049
	abnormal midbrain morphology	J:5049
	abnormal nasal cartilage morphology	J:5049
	abnormal nasal cavity morphology	J:5049
	abnormal nasal placode morphology	J:5049
	abnormal nasal septum morphology	J:5049
	abnormal neural tube morphology	J:5049
	abnormal neurocranium morphology	J:5049
	abnormal nose morphology	J:5049
	abnormal olfactory epithelium morphology	J:5049
	abnormal olfactory nerve morphology	J:5049
	abnormal olfactory tract morphology	J:5049
	abnormal optic chiasm morphology	J:5049
	abnormal optic cup morphology	J:5049
	abnormal optic stalk morphology	J:5049
	abnormal optic vesicle formation	J:5049
	abnormal orbitosphenoid bone morphology	J:5049
	abnormal otic capsule morphology	J:5049
	abnormal otic vesicle development	J:5049
	abnormal pericardium morphology	J:5049
	abnormal phalanx morphology	J:5049
	abnormal pharyngeal arch morphology	J:5049
	abnormal pubis morphology	J:5049
	abnormal rhombomere morphology	J:5049
	abnormal spine curvature	J:5049
	abnormal sternum morphology	J:5049
	abnormal superior semicircular canal morphology	J:5049
	abnormal telencephalon development	J:5049
	absent lateral semicircular canal	J:5049
	absent olfactory bulb	J:5049
	absent pineal gland	J:5049
	absent radius	J:5049
	absent tibia	J:5049
	acoria	J:5049
	anophthalmia	J:5049
	bowed fibula	J:5049
	decreased nipple number	J:5049
	delayed neural tube closure	J:5049
	ectopic adrenal gland	J:5049
	ectopic ovary	J:5049
	embryonic lethality during organogenesis, incomplete penetrance	J:5049
	enlarged first pharyngeal arch	J:5049
eyelids fail to open	J:5049
fused carpal bones	J:5049
fused tarsal bones	J:5049
fusion of vertebral arches	J:5049
Harderian gland hyperplasia	J:5049
hemorrhage	J:5049
increased total retina thickness	J:5049
microphthalmia	J:5049
omphalocele	J:5049
polydactyly	J:5049
prenatal lethality, incomplete penetrance	J:5049
retina fold	J:5049
sacral vertebral fusion	J:5049
short femur	J:5049
short nasal septum	J:5049
skin edema	J:5049
syndactyly	J:5049
thick apical ectodermal ridge	J:5049
thick nasal septum	J:5049
wavy neural tube	J:5049
Gli3Xt/Gli3Xt Glis1tm1Mnks/Glis1tm1Mnks mixed	abnormal brain morphology	J:80052
	polydactyly	J:80052
Gli3Xt/? Kif7maki/Kif7maki Tg(Hlxb9-GFP)1Tmj/? involves: 101/H * C3H/HeH * C57BL/6J * CBA/H * FVB/N	abnormal neural tube morphology	J:151965