Sox10^tm1Weg
Targeted Allele Detail

Summary

• Symbol: Sox10^tm1Weg
• Name: SRY (sex determining region Y)-box 10; targeted mutation 1, Michael Wegner
• MGI ID: MGI:2151173
• Synonyms: Sox10-, Sox10^lacZ, Sox10LacZ^KO
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^tm1Weg page

Lack of pigmentation and megacolon in Sox10^gt/Sox10^tm1Weg pups

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67383
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In-frame insertion of a lacZ-neomycin resistance cassette replaced the coding sequences. RT-PCR studies did not detect wild-type transcript in homozygous E12.5 embryos. (J:67383)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	905 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:67383 Britsch S, et al., The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 2001 Jan 1;15(1):66-78
• All: 61 reference(s)