All Phenotypes Sox10<tm1Weg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox10^tm1Weg
targeted mutation 1, Michael Wegner
MGI:2151173

Summary

20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox10^tm1Weg/Sox10^tm1Weg	involves: 129S1/Sv * 129X1/SvJ	MGI:3039429
hm2	Sox10^tm1Weg/Sox10^tm1Weg	involves: 129S1/Sv * 129X1/SvJ * C3H	MGI:6154210
hm3	Sox10^tm1Weg/Sox10^tm1Weg	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	MGI:5552013
ht4	Sox10^tm1Weg/Sox10⁺	C3HeB/FeJ-Sox10^tm1Weg	MGI:7461276
ht5	Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3039430
ht6	Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * C3H	MGI:6154211
ht7	Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	MGI:5552012
ht8	Sox10^gt/Sox10^tm1Weg	involves: 129S1/Sv * 129X1/SvJ * GT/Le	MGI:5648383
cx9	Mos3/Mos3⁺ Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:4462421
cx10	Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeH	MGI:5500163
cx11	Gli3^Mos1/Gli3⁺ Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:3797124
cx12	Erbb3^msp1/Erbb3^msp1 Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:3807570
cx13	Traf4^m1Pav/Traf4^m1Pav Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:3807571
cx14	Smarcc1^msp3/Smarcc1^msp3 Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:3807572
cx15	msp4/msp4 Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:3807573
cx16	Smarca4^mos6/Smarca4⁺ Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:6241342
cx17	Sox10^tm1Weg/Sox10⁺ Tg(Sox10)#Sout/0	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6 * SJL	MGI:7461278
cx18	Gli3^Xt-J/Gli3⁺ Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ	MGI:3797123
cx19	Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2	MGI:5515810
cx20	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * SJL	MGI:5515809

Allelic Composition	Sox10^tm1Weg/Sox10^tm1Weg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon fasciculation ( J:203636 )

• defasciculation of olfactory, vemeronasal, and terminal nerves

abnormal axon guidance ( J:203636 )

• olfactory, vomeronasal, and terminal nerves form, however axons are abnormally routed at E14.5; some do not target the olfactory bulb and instead contact axons from the other side, dorsally to the nasal septum

abnormal olfactory bulb morphology ( J:203636 )

• abnormal colonization of the olfactory bulbs by olfactory ensheathing cells at E14.5

• at E12.5, the migratory mass has already formed, however defective colonization of the olfactory-bulb anlage by olfactory ensheathing cells is seen on more rostral sections

• disorganization of the olfactory nerve layer of the olfactory bulbs

abnormal glial cell morphology ( J:203636 )

• almost complete absence of olfactory ensheathing cells in the nasal mesenchyme and along the nerve pathway and only a few are seen in the upper part of the frontonasal mesenchyme, under the migratory mass

• numerous olfactory ensheathing cells are present in the migratory mass and the olfactory nerve layer, but they appear to encircle the olfactory bulbs incompletely, forming a thinner, disorganized, and discontinuous layer

abnormal axon morphology ( J:203636 )

• axons of olfactory, vemeronasal, and terminal nerves are not ensheathed along their most ventral trajectory

cellular

abnormal axon fasciculation ( J:203636 )

• defasciculation of olfactory, vemeronasal, and terminal nerves

abnormal axon guidance ( J:203636 )

decreased cell migration ( J:203636 )

• gonadotropin-releasing hormone cells accumulate on the vomeronasal and terminal nerve trajectories in the nasal mesenchyme in E14.5 mutants unlike in controls in which the cells are migrating at this time within the two cerebral hemispheres, indicating impaired migration

embryo

abnormal frontonasal mesenchyme morphology ( J:203636 )

• absence of olfactory ensheathing cells in most of the nasal mesenchyme is already seen at E12.5

• gonadotropin-releasing hormone cells accumulate on the vomeronasal and terminal nerve trajectories in the nasal mesenchyme in E14.5 mutants unlike in controls in which gonadotropin-releasing hormone cells are migrating at this time within the two cerebral hemispheres

growth/size/body

abnormal frontonasal mesenchyme morphology ( J:203636 )

• absence of olfactory ensheathing cells in most of the nasal mesenchyme is already seen at E12.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kallmann syndrome		DOID:3614		J:203636

Allelic Composition	Sox10^tm1Weg/Sox10^tm1Weg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent Schwann cells ( J:260791 )

• spinal nerves of E18.5 mutants are devoid of Schwann cells

abnormal oligodendrocyte physiology ( J:260791 )

• the number of cells that have already started to express myelin genes such as Mbp and Plp1 are almost absent in the spinal cord at E18.5, indicating impaired differentiation of oligodendrocytes

Allelic Composition	Sox10^tm1Weg/Sox10^tm1Weg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:67383 )

• live embryos from the fourth or subsequent generations of backcrosses with C3HeB/FeJ are seen at expected numbers before and at E16.5 but at lower numbers at E18.5 (only 13.9%)

embryo

abnormal neural crest morphology ( J:67383 )

• mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ, distribution of neural crest cells at E10.5 is different from that in controls, with reduced numbers in cranial ganglia and along their projections, absence in the gut and reduced numbers in the sympathetic primordium

• at E12.5, severe reduction of neural crest cells along peripheral nerves is seen in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ

abnormal melanoblast morphology ( J:67383 )

• marker analysis indicates a severe and early loss of melanoblasts in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ

behavior/neurological

unresponsive to tactile stimuli ( J:67383 )

• mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ do not move or react to tactile stimulation

abnormal limb posture ( J:67383 )

• abnormal forelimb posture in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ

homeostasis/metabolism

cyanosis ( J:67383 )

• mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ are cyanotic at birth

nervous system

abnormal neural crest morphology ( J:67383 )

• at E12.5, severe reduction of neural crest cells along peripheral nerves is seen in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ

abnormal melanoblast morphology ( J:67383 )

• marker analysis indicates a severe and early loss of melanoblasts in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ

abnormal PNS glial cell morphology ( J:67383 )

• differentiated glia cells are absent in the peripheral nervous system of mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ

abnormal dorsal root ganglion morphology ( J:67383 )

• mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ, extensive and general apoptosis in dorsal root ganglia is seen at E11.5

pigmentation

decreased melanocyte number ( J:67383 )

• melanocytes are reduced in numbers in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ

respiratory system

respiratory failure ( J:67383 )

• mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ do not breathe at birth

Allelic Composition	Sox10^tm1Weg/Sox10⁺
Genetic Background	C3HeB/FeJ-Sox10^tm1Weg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

aganglionic megacolon ( J:296651 )

• hypo- or aganglionosis involving on average 3.1% of intestine length

integument

belly spot ( J:296651 )

pigmentation

belly spot ( J:296651 )

hypopigmentation ( J:296651 )

• white feet

Allelic Composition	Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

brain vacuoles ( J:216967 )

• mild vacuolation in the brain is seen starting between 7 and 8 months of age

Allelic Composition	Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

megacolon ( J:260791 )

• fewer than 5% of mice succumb to a megacolon around time of weaning

nervous system

abnormal oligodendrocyte physiology ( J:260791 )

• the number of Mbp and Plp-1 expressing oligodendrocytes are reduced in the spinal cord at P3 but not later times, indicating a slight and transient delay in oligodendroglial differentiation during the first postnatal days

• however, sciatic nerves, development and maintenance of Schwann cells and PNS myelin, and spinal cord development appear normal

integument

belly spot ( J:260791 )

• white belly spot is fully penetrant from second generation backcross to C3H and onwards

pigmentation

belly spot ( J:260791 )

• white belly spot is fully penetrant from second generation backcross to C3H and onwards

Allelic Composition	Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:67383 )

• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, a significant proportion of heterozygotes are lost during the first postnatal weeks; at weaning, only 38.2% of heterozygotes are seen instead of the expected 50% but expected numbers are seen perinatally

digestive/alimentary system

megacolon ( J:67383 )

• a fraction of heterozygotes from the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice exhibit megacolon

integument

belly spot ( J:67383 )

• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, heterozygotes display a white belly spot

pigmentation

belly spot ( J:67383 )

• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, heterozygotes display a white belly spot

decreased melanocyte number ( J:67383 )

• melanocytes are reduced in numbers in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ

Allelic Composition	Sox10^gt/Sox10^tm1Weg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * GT/Le

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^gt mutation (0 available); any Sox10 mutation (33 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lack of pigmentation and megacolon in Sox10^gt/Sox10^tm1Weg pups

mortality/aging

postnatal lethality, complete penetrance ( J:216967 )

• mice survive to birth but most die within 4-5 days after birth

digestive/alimentary system

megacolon ( J:216967 )

• all mice develop severe and fatal megacolon

integument

absent coat pigmentation ( J:216967 )

• mice have pigmented eyes but white fur

nervous system

brain vacuoles ( J:216967 )

pigmentation

absent coat pigmentation ( J:216967 )

• mice have pigmented eyes but white fur

decreased melanocyte number ( J:216967 )

• lack of skin melanocytes

Allelic Composition	Mos3/Mos3⁺ Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mos3 mutation (0 available); any Mos3 mutation (0 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

hypopigmentation ( J:136642 )

• increased ventral hypopigmentation compared to Sox10^tm1Weg/+, and is accompanied by dorsal hypopigmentation

Allelic Composition	Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps7^Zma mutation (0 available); any Rps7 mutation (16 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺ embryos show greatly reduced melanoblast number at E12.5 as compared to E12.5 Sox10^tm1Weg/Sox10⁺ mice

pigmentation

belly spot ( J:195156 )

• increased compared to in Rps7^Zma heterozygotes

hypopigmentation ( J:195156 )

• increased compared to in Sox10^tm1Weg heterozygotes without dark skin on the foot pads and tail

limbs/digits/tail

kinked tail ( J:195156 )

growth/size/body

decreased body size ( J:195156 )

nervous system

abnormal melanoblast morphology ( J:195156 )

• reduced numbers in the head and trunk at E12.5, more so than in Rps7^Zma heterozygotes

integument

belly spot ( J:195156 )

• increased compared to in Rps7^Zma heterozygotes

embryo

abnormal melanoblast morphology ( J:195156 )

• reduced numbers in the head and trunk at E12.5, more so than in Rps7^Zma heterozygotes

Allelic Composition	Gli3^Mos1/Gli3⁺ Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Mos1 mutation (0 available); any Gli3 mutation (80 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belted ( J:136642 )

• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10^tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region

belly spot ( J:136642 )

• mice exhibit ventral hypopigmentation

hypopigmentation ( J:136642 )

• mice exhibit more hypopigmentation than in either single heterozygote

integument

belted ( J:136642 )

belly spot ( J:136642 )

• mice exhibit ventral hypopigmentation

Allelic Composition	Erbb3^msp1/Erbb3^msp1 Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^msp1 mutation (0 available); any Erbb3 mutation (47 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:138775 )

• fewer than expected mice are present at E12.5, E13.5, and E16.5

embryonic lethality during organogenesis, incomplete penetrance ( J:138775 )

• fewer than expected mice are present at E12.5, E13.5, and E16.5

preweaning lethality, complete penetrance ( J:138775 )

• no mice survive to weaning

pigmentation

hypopigmentation ( J:138775 )

Allelic Composition	Traf4^m1Pav/Traf4^m1Pav Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Traf4^m1Pav mutation (1 available); any Traf4 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:138775 )

• fewer than expected mice survive to weaning

pigmentation

hypopigmentation ( J:138775 )

Allelic Composition	Smarcc1^msp3/Smarcc1^msp3 Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcc1^msp3 mutation (0 available); any Smarcc1 mutation (69 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:138775 )

• no mice survive to weaning

nervous system

open neural tube ( J:138775 )

pigmentation

hypopigmentation ( J:138775 )

embryo

open neural tube ( J:138775 )

Allelic Composition	msp4/msp4 Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
msp4 mutation (0 available); any msp4 mutation (0 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:138775 )

• fewer than expected mice survive to weaning

pigmentation

hypopigmentation ( J:138775 )

Allelic Composition	Smarca4^mos6/Smarca4⁺ Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4^mos6 mutation (0 available); any Smarca4 mutation (109 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:241206 )

• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10^tm1Weg heterozygotes

head spot ( J:241206 )

• adult double heterozygous mice exhibit a head spot

integument

belly spot ( J:241206 )

• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10^tm1Weg heterozygotes

head spot ( J:241206 )

• adult double heterozygous mice exhibit a head spot

embryo

abnormal melanoblast morphology ( J:241206 )

• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10^tm1Weg heterozygotes

nervous system

abnormal melanoblast morphology ( J:241206 )

• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10^tm1Weg heterozygotes

Allelic Composition	Sox10^tm1Weg/Sox10⁺ Tg(Sox10)#Sout/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Sox10)#Sout mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:296651 )

N	• no hypo- or aganglionosis of intestines

integument

integument phenotype ( J:296651 )

N	• no belly spot or white feet

pigmentation

pigmentation phenotype ( J:296651 )

N	• no belly spot or white feet

Allelic Composition	Gli3^Xt-J/Gli3⁺ Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belted ( J:136642 )

belly spot ( J:136642 )

• mice exhibit ventral hypopigmentation

hypopigmentation ( J:136642 )

• mice exhibit more hypopigmentation than in either single heterozygote

integument

belted ( J:136642 )

belly spot ( J:136642 )

• mice exhibit ventral hypopigmentation

Allelic Composition	Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:193443 )

N	• hyperproliferation is not observed in the melanocytic cells localized to hair follicles as is seen in single Tg(Tyr-NRAS*Q61K)1Bee mutants

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:193443 )

N	• loss of the hyperpigmentation that is seen in Cdkn2a^tm1Rdp/ Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/0 mice resulting in an almost normal pigmentation pattern

neoplasm

neoplasm ( J:193443 )

N	• no signs of primary melanoma formation are seen at 6 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23