Erbb3^msp1
Chemically induced Allele Detail

Summary

• Symbol: Erbb3^msp1
• Name: erb-b2 receptor tyrosine kinase 3; modifier of Sox10 expression pattern 1
• MGI ID: MGI:3722389
• Synonyms: msp1
• Gene: Erbb3 Location: Chr10:128403392-128425504 bp, - strand Genetic Position: Chr10, 77.1 cM
• Alliance: Erbb3^msp1 page

Mutation origin

• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU mutation was identified in a screen for alteration in the neural crest expression pattern of the lacZ reporter allele Sox10 (Sox10^tm1Weg). The ENU mutation is an A-to-G transition in exon 8 (A1136G) that results in replacement of aspartic acid with glycine at amino acid position 294 (D294G). (J:138775)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb3 Mutation: 47 strains or lines available

References

• Original: J:138775 Buac K, et al., A Sox10 expression screen identifies an amino acid essential for Erbb3 function. PLoS Genet. 2008 Sep;4(9):e1000177
• All: 2 reference(s)